{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:00:45Z","timestamp":1785549645154,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Inflammatory and non\u2010inflammatory acne lesions constitute a significant clinical challenge in acne subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid for improving skin conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomized controlled trial included adults with comedones, post\u2010inflammatory erythema (PIE) and\/or hyperpigmentation (PIH) in Shanghai, China in July 2021. Participants were randomly assigned 1:1 to receive the study Serum\u2009+\u2009Mask or serum alone for 8\u2009weeks. Acne severity, comedones, papules, pustules, PIE, PIH, skin pores, skin tone evenness, sebum secretion, skin hydration, and trans\u2010epidermal water loss were evaluated at T0d, T1d, T7d, T14d, T28d, and T56d.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010three participants were included, including 41 and 42 in the Serum\u2009+\u2009Mask and Serum groups, respectively. Acne severity, density of skin pores, skin tone evenness, PIH foci on face, PIE foci on nose, intensity of PIE and PIH, closed comedones on face, open comedones on nose, sebum secretion, and skin hydration were significantly improved from baseline after 8\u2009weeks of treatment in both groups (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Addition of the mask improved the number of closed comedones (\u22126.56\u2009\u00b1\u20090.39 vs. \u22125.19\u2009\u00b1\u20090.44, <jats:italic>p<\/jats:italic>\u2009=\u20090.022) and acne severity (\u22120.39\u2009\u00b1\u20090.08 vs. \u22120.12\u2009\u00b1\u20090.09, <jats:italic>p<\/jats:italic>\u2009=\u20090.026) substantially more than using the serum alone. No adverse reaction was reported in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study serum improved skin conditions by regulating skin barrier function and achieving a balance of skin hydration and sebum secretion, removing comedones and improving PIE and PIH. Addition of the mask accelerated the effects without compromising safety.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15746","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T09:12:21Z","timestamp":1680253941000},"page":"2502-2511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid in acne management: A randomized controlled trial"],"prefix":"10.1111","volume":"22","author":[{"given":"Shuting","family":"Li","sequence":"first","affiliation":[{"name":"Research and Innovation Center L'Or\u00e9al China  Shanghai 201206 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"He","sequence":"additional","affiliation":[{"name":"Research and Innovation Center L'Or\u00e9al China  Shanghai 201206 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Active Cosmetics Division L'Or\u00e9al China  Shanghai 200040 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghua (Succi)","family":"Zhang","sequence":"additional","affiliation":[{"name":"Active Cosmetics Division L'Or\u00e9al China  Shanghai 200040 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqing (Gloria)","family":"Niu","sequence":"additional","affiliation":[{"name":"Research and Innovation Center L'Or\u00e9al China  Shanghai 201206 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Steel","sequence":"additional","affiliation":[{"name":"Research and Innovation Center L'Or\u00e9al China  Shanghai 201206 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hequn (Tracy)","family":"Wang","sequence":"additional","affiliation":[{"name":"Research and Innovation Center L'Or\u00e9al China  Shanghai 201206 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11102744"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15186"},{"issue":"3","key":"e_1_2_11_4_1","article-title":"Post\u2010acne hyperpigmentation: evaluation of risk factors and the use of artificial neural network as a predictive classifier","volume":"13","author":"Al\u2010Qarqaz F","year":"2021","journal-title":"Dermatol Rep"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13263"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00633-4"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S76088"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.17633"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-019-00423-z"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/12034754211045391"},{"issue":"1","key":"e_1_2_11_11_1","first-page":"65","article-title":"Comedolysis by a lipohydroxyacid formulation in acne\u2010prone subjects","volume":"13","author":"Uhoda E","year":"2003","journal-title":"Eur J Dermatol"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14948"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14016"},{"issue":"3","key":"e_1_2_11_14_1","first-page":"266","article-title":"Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris","volume":"12","author":"Baumann LS","year":"2013","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.04.104"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13579"},{"key":"e_1_2_11_17_1","article-title":"Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha\u2010hydroxy acid) for acne","volume":"5","author":"Liu H","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-019607"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00039.2012"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2016.06.002"},{"issue":"4","key":"e_1_2_11_21_1","first-page":"40","article-title":"Randomized, placebo\u2010controlled study of a nutraceutical based on hyaluronic acid, L\u2010carnosine, and Methylsulfonylmethane in facial skin aesthetics and well\u2010being","volume":"12","author":"Guaitolini E","year":"2019","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200809030-00010"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174458"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-05351-3"},{"issue":"8","key":"e_1_2_11_25_1","article-title":"Mechanistic basis and clinical evidence for the applications of nicotinamide (Niacinamide) to control skin aging and pigmentation","volume":"10","author":"Boo YC","year":"2021","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110023"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15746","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T10:29:46Z","timestamp":1691749786000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.15746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,31]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/jocd.15746"],"URL":"https:\/\/doi.org\/10.1111\/jocd.15746","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,31]]},"assertion":[{"value":"2022-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}