{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T03:24:56Z","timestamp":1781321096782,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Art Filler Volume (AFV) is a hyaluronic acid (HA)\u2010based filler formulated with \u201cTri\u2010Hyal\u201d technology, a unique combination of three sizes of HA chains. This study assessed AFV efficacy and safety over 18\u2009months when used to restore midface volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>During this open\u2010label study, a maximum of 1.8\u2009mL AFV was injected into each cheek area on Day 0 (D0). Subjects were evaluated at D21, when, if necessary, a retouch could be performed (maximum 1.2\u2009mL per cheek). Subjects were evaluated at seven follow\u2010up visits through to D540. The primary assessment was based on the evolution of the Medicis Midface Volume Scale (MMVS) grade on D21. Secondary outcomes were local and general adverse events, investigator\u2010 and subject\u2010assessed Global Aesthetic Improvement Scale scores and changes in self\u2010esteem.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 79 healthy Caucasians enrolled (mean age 54.8\u2009years), 25 required a second injection. In the intention\u2010to\u2010treat population, mean overall MMVS scores improved significantly from D0 (3.2\u2009\u00b1\u20090.4) to D21 (1.8\u2009\u00b1\u20090.6) and D42 (1.7\u2009\u00b1\u20090.6) (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). MMVS scores for each cheek also improved significantly, irrespective of retouch on D21: 22% of injections showed a persistent benefit at D540 without retouch. The most common adverse events were pain on palpation (19%), erythema (15%) and edema (13%); most were mild or moderate and resolved within 2\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AFV produces a sustained objective and subjective midface volume restoration in female and male subjects, often without retouching, and was well tolerated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15752","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T07:52:11Z","timestamp":1683013931000},"page":"2448-2456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Long\u2010term efficacy and safety of a hyaluronic acid dermal filler based on <scp>Tri\u2010Hyal<\/scp> technology on restoration of midface volume"],"prefix":"10.1111","volume":"22","author":[{"given":"Philippe","family":"Kestemont","sequence":"first","affiliation":[{"name":"MEDITI Center  90 Boulevard Francis Meiland, 06160 Juan\u2010les\u2010pins France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3900-5506","authenticated-orcid":false,"given":"Ferial","family":"Fanian","sequence":"additional","affiliation":[{"name":"Laboratoires FILLMED  2\u20104 Rue de Lisbonne 75008 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Garcia","sequence":"additional","affiliation":[{"name":"Clinique R\u00e9musat  21 Rue de R\u00e9musat 75016 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Grand\u2010Vincent","sequence":"additional","affiliation":[{"name":"Private Practice  97 Avenue de Villiers 75017 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Benadiba","sequence":"additional","affiliation":[{"name":"Private Practice  86 Avenue Foch 75116 Paris 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