{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:26:26Z","timestamp":1780586786648,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>People with oily skin often suffer from skin problems such as oily face, blackheads, acne, and enlarged pores. It is necessary to regulate oily skin with skin care products.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To develop an effective sebum control essence to reduce oiliness of skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The composition of the essence was designed in consideration of different oil control mechanism targets. The skin irritation was assessed in 30 volunteers by a single application close patch test. The efficacy of the essence was evaluated by in vitro experiment, short\u2010 and long\u2010term clinical trials with over 60 volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results of both in vitro and clinical trials showed that the essence had significant oil control and moisturizing effect, the skin oil content decreased by 21.8% within 8\u2009h and 30.05% after 28\u2009days, which indicated that the essence could achieve rapid and persistent sebum control efficacy. In addition, the essence could relieve the problems of enlarged pores, blackheads and whiteheads in long\u2010term use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The essence developed in this study can alleviate the problems of oily skin from many aspects, and achieve an excellent effect in oily skin regulation. It is suitable for a daily application in oily skin regulation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15764","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T07:41:47Z","timestamp":1682667707000},"page":"2605-2611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["In vitro and in vivo study of the efficacy of a new sebum control essence"],"prefix":"10.1111","volume":"22","author":[{"given":"Juan","family":"Wei","sequence":"first","affiliation":[{"name":"Hangzhou CNFormulator Technology Co., Ltd  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Ma","sequence":"additional","affiliation":[{"name":"Hangzhou CNFormulator Technology Co., Ltd  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Hangzhou CNFormulator Technology Co., Ltd  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Pan","sequence":"additional","affiliation":[{"name":"Hangzhou CNFormulator Technology Co., Ltd  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Pang","sequence":"additional","affiliation":[{"name":"Hangzhou CNFormulator Technology Co., Ltd  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13347"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12244"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12791"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12168"},{"key":"e_1_2_11_6_1","first-page":"41","article-title":"Surface lipids as multifunctional mediators of skin responses to environmental stimuli","volume":"50","author":"De Luca C","year":"2010","journal-title":"Mediators Inflamm"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.03.011"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-019-01908-x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00254"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-016-0138-1"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.12.037"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13503"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/10799893.2020.1805626"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13319"},{"issue":"5","key":"e_1_2_11_15_1","first-page":"412","article-title":"Cortexolone 17 alpha\u2010propionate (Clascoterone) is a novel androgen receptor antagonist that inhibits production of lipids and inflammatory cytokines from sebocytes in vitro","volume":"18","author":"Rosette C","year":"2019","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.0704a08"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-020-00542-y"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12134.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2494.2007.00360.x"},{"key":"e_1_2_11_20_1","unstructured":"HumbertP FanianF MaibachHI AgacheP.Agache's Measuring the Skin: Non\u2010invasive Investigation Physiology Normal Constants(2nd ed.) 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