{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T21:17:20Z","timestamp":1788556640806,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne vulgaris is a common skin disease that is more common in young population and it can be associated with some sequels after resolving the lesions. Post\u2010inflammatory erythema is one of these complications that can be disturbing for patients and does not have any definite treatment. This study was aimed to evaluate the efficacy and safety of tranexamic acid (TA) as mesotherapy in treatment of post\u2010acne erythema (PAE) treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This clinical trial study was performed in the dermatology clinic on 17 patients with persistent PAE (3\u2009months after acne recovery). Two sessions of treatment were performed by a physician with 2\u2010week intervals; TA was injected as mesotherapy into the right side of each patient's face as the case group, while the opposite side was used as the control group. A Visioface device was used to compare before and after treatment photographs of each side of the face in color mode with quantitative measures such as lesions count, area, and area percent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Finally, 15 patients completed treatment sessions. There were statistically significant differences in right side lesions before and after treatment with<jats:italic>p<\/jats:italic>\u2010values of 0.047, 0.002, and 0.035 for count, area, and area percent, respectively. There was no significant difference before and after treatment in terms of count, area. and area\u2010percent on the left side.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>According to the results of this study, TA injection as mesotherapy for resolving PAE can be effective. However, due to small sample size, further studies are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15776","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T07:15:11Z","timestamp":1682061311000},"page":"2714-2720","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Evaluating the effect of tranexamic acid as mesotherapy on persistent post\u2010acne erythema: A before and after study"],"prefix":"10.1111","volume":"22","author":[{"given":"Afsaneh Sadeghzadeh","family":"Bazargan","sequence":"first","affiliation":[{"name":"Department of Dermatology, Rasoul Akram Hospital Iran University of Medical Sciences (IUMS) Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Ziaeifar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rasoul Akram Hospital Iran University of Medical Sciences (IUMS) Tehran 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