{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:36:22Z","timestamp":1780414582540,"version":"3.54.1"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The recent removal of hydroquinone from the over\u2010the\u2010counter market has created a need for modern skin lightening formulations. An effective pigment lightening formulation must be non\u2010irritating to prevent skin darkening from post\u2010inflammatory hyperpigmentation, penetration enhanced to reach the epidermal\/dermal junction, contain anti\u2010inflammatory ingredients, and address multiple mechanisms of pigment production.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this research was to demonstrate the efficacy of a topical multimodal pigment lightening preparation containing tranexamic acid, niacinamide, and licorice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty female subjects 18+ years of all Fitzpatrick skin types with mild to moderate facial dyspigmentation were enrolled. Subjects were provided with the study product for twice daily use on the entire face and an SPF50 sunscreen with evaluations occurring at Week 4, Week 8, Week 12, and Week 16.<\/jats:p><jats:p>The investigator used a face map to identify a pigmented target site on the face for dermaspectrophotometer (DSP) measurement. The dermatologist investigator completed a baseline facial efficacy and tolerability assessment. The subjects completed a tolerability assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>48\/50 subjects completed the study without tolerability issues. The DSP readings demonstrated a statistically significant reduction in target spot pigmentation at Week 16. The investigator assessed a 37% decrease in pigment intensity, a 31% decrease in pigment extent, a 30% decrease in pigment homogeneity, a 45% improvement in brightness, a 42% improvement in clarity, and a 32% improvement in overall facial skin dyspigmentation at Week 16.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of penetration enhanced tranexamic acid, niacinamide, and licorice was effective in inducing facial pigment lightening.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15786","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T06:49:20Z","timestamp":1682578160000},"page":"1799-1804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The clinical benefit of a multimodal topical approach to treating skin dyspigmentation"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9803-7415","authenticated-orcid":false,"given":"Zoe Diana","family":"Draelos","sequence":"first","affiliation":[{"name":"Dermatology Consulting Services, PLLC  High Point North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Diaz","sequence":"additional","affiliation":[{"name":"Colgate\u2010Palmolive Company  Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2007.00144.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1091581810385957"},{"issue":"3","key":"e_1_2_10_4_1","first-page":"66","article-title":"Tranexamic acid: an emerging depigmenting agent","volume":"2","author":"Anju G","year":"2022","journal-title":"Pigment Int"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2021.1914313"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12759"},{"key":"e_1_2_10_7_1","first-page":"20","article-title":"The use of botanical extracts as topical skin\u2010lightening agents for the improvement of skin pigmentation disorders","volume":"13","author":"Zhy W","year":"2008","journal-title":"J Inv Dermatol"},{"issue":"2","key":"e_1_2_10_8_1","first-page":"76","article-title":"Complementary and alternative medicine treatments for common skin diseases: a systematic review and meta\u2010analysis","volume":"26","author":"Jones VA","year":"2020","journal-title":"JAAD Int"},{"key":"e_1_2_10_9_1","article-title":"The synergistic anti\u2010irritant effects of alpha\u2010bisabolol and ginger","author":"Herrmann M","year":"2008","journal-title":"Cosmet Toilet"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-021-00566-0"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2010.00616.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1091581810385956"},{"issue":"5","key":"e_1_2_10_13_1","first-page":"19","article-title":"Topical treatments for melasma and their mechanism of action","volume":"15","author":"Gonz\u00e1lez\u2010Molina V","year":"2022","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14746"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T18:31:37Z","timestamp":1700677897000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.15786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,26]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/jocd.15786"],"URL":"https:\/\/doi.org\/10.1111\/jocd.15786","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,26]]},"assertion":[{"value":"2023-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}