{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:26:03Z","timestamp":1791483963335,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Little is known about antioxidant efficacy of topical vitamin E on atopic dermatitis (AD) due to lack of controlled clinical studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The study evaluates the effectiveness and safety of a topical moisturizer containing tocotrienol\u2010rich composition over 12\u2009weeks on patients aged between 1\u2009month and 12\u2009years with mild to moderate AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a 12\u2009weeks, prospective, open\u2010label clinical study on the effect of tocotrienol as an adjunct to conventional treatment. This study was approved by the Ethics Committee for Research Involving Human Subject. JKEUPM\u20102019\u2010274 (NMMR\u201019\u20101588\u201049234).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty AD patients with a mean age of 2.77\u2009\u00b1\u20093.05 were enrolled in the study. At week\u201012, significant reduction of investigator global assessment (63.4%), Patient\u2010Oriented Scoring Atopic Dermatitis Index (PO\u2010SCORAD) (65%), and SCORAD (52.3%) was noted (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). There was also a significant decreased in pruritus intensity (46%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Similarly at week\u201012, Infant's Dermatitis Quality of Life Index and Children's Dermatology Life Quality Index were found to improve significantly compared to baseline (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Instrumental assessment revealed improvement in TEWL and erythema index, 49.7% and 17.4%, respectively. No adverse reaction was observed. 95% of patients were satisfied with the moisturizer and 90% perceived it to be better than the one in the market. There was a 55.07% reduction in the use of hydrocortisone 1% cream toward the end of the study (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results suggested that tocotrienol\u2010rich moisturizer is safe and effective in the management of AD in young children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15793","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T02:45:26Z","timestamp":1683254726000},"page":"2746-2754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Open\u2010label, single\u2010arm, single\u2010center clinical study on the effectiveness and safety of a moisturizer containing tocotrienol\u2010rich composition in children with mild to moderate atopic dermatitis"],"prefix":"10.1111","volume":"22","author":[{"given":"Kang Nien","family":"How","sequence":"first","affiliation":[{"name":"Dermatology Unit, Faculty of Medicine and Health Sciences Universiti Putra Malaysia  Serdang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hon Weng","family":"Chang","sequence":"additional","affiliation":[{"name":"Lipidware Sdn. Bhd., G\u201005, Jalan Maklumat, MTDC\u2010UPM Universiti Putra Malaysia  Serdang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oi Ming","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences Universiti Putra Malaysia  Serdang Malaysia"},{"name":"Institute of Bioscience Universiti Putra Malaysia  Serdang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"issue":"8","key":"e_1_2_10_2_1","first-page":"S115","article-title":"Overview of atopic dermatitits","volume":"23","author":"Avena\u2010Woods C","year":"2017","journal-title":"Am J Manag Care"},{"issue":"3","key":"e_1_2_10_3_1","first-page":"183","article-title":"Therapies to improve cosmetic symptoms of atopic dermatitis","volume":"97","author":"Kessel J","year":"2016","journal-title":"Cutis"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.58.161"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1991.tb01878.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4236\/jcdsa.2012.21009"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2010.10018"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2010.09083"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-13-335"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02577.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2721469"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.175"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000056395"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-010-0863-0"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpx.2019.100025"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2005.00340.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2017.05.055"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1139\/y93-109"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.425"},{"issue":"1","key":"e_1_2_10_20_1","first-page":"31","article-title":"Effects of combination treatment with vitamins E and C on chloasma and pigmented contact dermatitis. 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