{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:21:10Z","timestamp":1781796070968,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Conditioned media (CM) derived from mesenchymal stem cells (MSC) is known to induce hair regrowth in androgenic alopecia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objectives of the study were to assess the efficacy and safety of one type of MSC\u2010CM, the CM derived from dental pulp stem cells obtained from human exfoliated deciduous teeth (SHED\u2010CM) and to compare the efficacy of SHED\u2010CM with and without dihydrotestosterone synthesis inhibitor (DHT\u2010inhibitor).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010eight male androgenic alopecia subjects with Hamilton\u2010Norwood Classification (H\u2010N C) I\u2013VII were evaluated by trichoscopy to explore which trichoscopic factors statistically correlated with H\u2010N C. After being screened, 33 subjects received six SHED\u2010CM treatments at 1\u2010month intervals. Clinical severity was assessed through global and trichoscopic images from baseline to 9th month.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SHED\u2010CM was effective for 75% of subjects regardless of disease severity, concomitant DHT\u2010inhibitor use, and age. Adverse effects including pain and small hemorrhages were transient and mild. We also found that clinical hair status evaluated by absolute values of three quantitative trichoscopic factors (maximum hair diameter, vellus hair rate, and multi\u2010hair follicular unit rate) showed a good correlation with H\u2010N C stages, and what is more\u2014a scoring system of these three factors can be a possible predictor of SHED\u2010CM efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have shown that SHED\u2010CM provides global and trichoscopic image improvement for androgenic alopecia, regardless of concomitant DHT\u2010inhibitor use.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15799","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T12:10:11Z","timestamp":1683547811000},"page":"3107-3117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Trichoscopic evaluation of dental pulp stem cell conditioned media for androgenic alopecia"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5929-6166","authenticated-orcid":false,"given":"Tomoko","family":"Kamishima","sequence":"first","affiliation":[{"name":"Department of Dermatology Tokyo Midtown Skin\/Aesthetic Clinic Noage  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Hirabe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Midtown Skin\/Aesthetic Clinic Noage  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Ohnishi","sequence":"additional","affiliation":[{"name":"Tokyo Midtown Dental Clinic  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Tokyo Midtown Clinic  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5553-1245","authenticated-orcid":false,"given":"Khin Zay Yar","family":"Myint","sequence":"additional","affiliation":[{"name":"Tokyo Midtown Center for Advanced Medical Science and Technology  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Koga","sequence":"additional","affiliation":[{"name":"Ginza Solaria Clinic  Tokyo Japan"},{"name":"Panagy Co., Ltd.  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