{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T11:58:10Z","timestamp":1771675090687,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Syringoma is a common but refractory benign skin tumor. Conventional treatment, such as ultra\u2010pulsed carbon dioxide (CO<jats:sub>2<\/jats:sub>) laser or cryotherapy, often requires multiple treatment and can easily cause prolonged erythema, scarring, or depression, which are frustrating, so there is an urgent need to seek a safer and more effective method. In this article, we tried to demonstrate the Er:YAG laser combined with botulinum toxin A (BTXA) as a safer and more efficacious method for treating syringomas. Materials and methods: Twenty\u2010one patients with local syringomas were treated with erbium laser ablation. Immediately after laser treatment, approximately 10\u2009units of BTXA were sprayed on the wound for 10\u2009min. Result: In total, 21 patients underwent 1.62\u2009\u00b1\u20090.74 treatments; their Periorbital Syringoma Severity Index (PSSI) score declined from 4.19 (before treatment) to 1.10 (after treatment), and the number of treatments was significantly lower than those reported in previous literature using the erbium laser alone. Conclusion: The Er:YAG laser combined with botulinum toxin A for the treatment of syringoma is a safer and more effective treatment than traditional treatment methods.<\/jats:p>","DOI":"10.1111\/jocd.15800","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T11:25:08Z","timestamp":1683890708000},"page":"2721-2728","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Er:<scp>YAG<\/scp> laser combined with botulinum toxin A for patients with local syringomas: A preliminary report"],"prefix":"10.1111","volume":"22","author":[{"given":"Bin","family":"Yao","sequence":"first","affiliation":[{"name":"Center for Plastic &amp; Reconstructive Surgery, Department of Orthopedics Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College)  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Chen","sequence":"additional","affiliation":[{"name":"Hangzhou YiJia medical cosmetology clinic Dermatology Department  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilei","family":"Wu","sequence":"additional","affiliation":[{"name":"Changshuo Street Health Center Surgery Department  Huzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinhao","family":"Gu","sequence":"additional","affiliation":[{"name":"Center for Plastic &amp; Reconstructive Surgery, Department of Plastic &amp; Reconstructive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College)  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1729-6744","authenticated-orcid":false,"given":"Wei","family":"Feng","sequence":"additional","affiliation":[{"name":"Center for Plastic &amp; Reconstructive Surgery, Department of Plastic &amp; Reconstructive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College)  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.12.006"},{"issue":"3","key":"e_1_2_11_3_1","article-title":"Progress made in laser therapy for syringoma","volume":"27","author":"Ying Z","year":"2018","journal-title":"Chin J Laser Med Surg"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2016.1157361"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2015.1052517"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjz288"},{"issue":"32","key":"e_1_2_11_7_1","first-page":"194","article-title":"Syringomas. Pan","volume":"18","author":"Agharbi F\u2010Z","year":"2019","journal-title":"Afr Med"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2015.1027224"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-020-02950-2"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2012.01612.x"},{"issue":"2","key":"e_1_2_11_11_1","first-page":"661","article-title":"Botulinum toxin type a prevents the phenotypic transformation of fibroblasts induced by TGF\u2010\u03b21 via the PTEN\/PI3K\/Akt signaling pathway","volume":"44","author":"Zhang X","year":"2019","journal-title":"Int J Mol Med"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.109854"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T07:28:57Z","timestamp":1695108537000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.15800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,12]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/jocd.15800"],"URL":"https:\/\/doi.org\/10.1111\/jocd.15800","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,12]]},"assertion":[{"value":"2022-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}