{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T20:24:13Z","timestamp":1787689453378,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007280","name":"Srinakharinwirot University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007280","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Seborrhea leads to facial greasiness and unpleasant feeling. People with seborrhea also have trouble with selecting moisturizers. <jats:sc>l<\/jats:sc>\u2010Carnitine and epigallocatechin gallate (EGCG) are reported anti\u2010sebum properties. However, neither efficacy comparison nor the combination effect of the two topical anti\u2010sebum agents was studied. Moisturizing cream with these agents is supposed to provide skin with an optimal water\u2013oil balance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare the efficacy of moisturizer containing 2% <jats:sc>l<\/jats:sc>\u2010carnitine or 5% EGCG alone on sebum controlling, and the synergistic effect of these two agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three study creams were formulated by adding three kinds of anti\u2010sebum agents which were 2% <jats:sc>l<\/jats:sc>\u2010carnitine, 5% EGCG, and 2% <jats:sc>l<\/jats:sc>\u2010carnitine plus 5% EGCG in moisturizing cream base of dimethicone and glycerin. A randomized clinical trial was conducted. Ninety subjects, divided into three groups, applied the cream for 4\u2009weeks. Sebum level, skin capacitance, and transepidermal water loss (TEWL) were evaluated at Weeks 0, 1, 2, and 4. Life qualities and subjective outcomes were assessed before and after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean sebum reduction from baseline was statistically significant in all treatment groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The median time to oil control was longer in <jats:sc>l<\/jats:sc>\u2010carnitine group. The combine group had significantly greater anti\u2010sebum efficacy than <jats:sc>l<\/jats:sc>\u2010carnitine group (<jats:italic>p<\/jats:italic>\u2009=\u20090.009). All three groups had significant improvement of other objective parameters and subjective outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The anti\u2010sebum moisturizing cream exhibited beneficial effect on the sebum reduction with improve skin hydration in people with seborrhea and made users satisfied. The EGCG group and the combine group show the greater anti\u2010sebum effect than the <jats:sc>l<\/jats:sc>\u2010carnitine group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15816","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T11:19:56Z","timestamp":1684322396000},"page":"3058-3064","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of anti\u2010sebum moisturizing cream containing 2% <scp>l<\/scp>\u2010carnitine and 5% epigallocatechin gallate in seborrhea: A randomized clinical trial"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0270-2343","authenticated-orcid":false,"given":"Pipatpong","family":"Detudom","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Srinakharinwirot University  Bangkok 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