{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T02:46:33Z","timestamp":1773197193477,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In any dermatologic procedure, patient acceptance of treatment is heavily influenced by intraprocedural pain. Intralesional triamcinolone injections are very important in keloid scar and nodulocystic acne treatment. However, the main problem of needle\u2010stick procedures is pain. Cryoanesthesia is ideally intended to cool only the epidermis during treatment and has advantage which did not require application time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to investigate the pain\u2010reducing effect and safety of CryoVIVE\u00ae (newly introduced cryoanesthesia device) during triamcinolone injections for nodulocystic acne in actual clinical settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>In this two\u2010staged, non\u2010randomized clinical trial, a total of 64 subjects underwent intralesional triamcinolone injections for their acne lesions with cold anesthesia using CryoVIVE\u00ae. The pain intensity was assessed with Visual Analogue Scale (VAS) scores. Safety profile was also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean pain VAS scores on the lesion with and without cold anesthesia were 3.667 and 5.933, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.0001). No side effects, discoloration, and scarring were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, the anesthetic use of CryoVIVE\u00ae with intralesional corticosteroid injections is a practical and well\u2010tolerated modality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15829","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T10:10:15Z","timestamp":1684836615000},"page":"3375-3378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cold anesthesia for pain reduction during intralesional steroid injection for nodulocystic acne"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9314-6401","authenticated-orcid":false,"given":"Su Jung","family":"Park","sequence":"first","affiliation":[{"name":"Department of Dermatology Soonchunhyang University College of Medicine  Cheonan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Hye","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chung\u2010Ang University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6376-0328","authenticated-orcid":false,"given":"Young Gue","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chung\u2010Ang University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gun\u2010Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Ulsan National Institute of Science and Technology  Ulsan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nark Kyoung","family":"Rho","sequence":"additional","affiliation":[{"name":"Leaders Aesthetic Laser &amp; Cosmetic Surgery Center  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chung\u2010Ang University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","first-page":"99","article-title":"Percutaneous dermal drug delivery for local pain control","volume":"2","author":"Tadicherla S","year":"2006","journal-title":"Ther Clin Risk Manag"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001040"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1992.tb02764.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.106506"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.01.026"},{"issue":"12","key":"e_1_2_10_7_1","first-page":"41","article-title":"Dermatologist use of Intralesional triamcinolone in the treatment of acne","volume":"13","author":"Gallagher T","year":"2020","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1963.01590140045008"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1995.tb01351.x"},{"issue":"8","key":"e_1_2_10_10_1","first-page":"463","article-title":"EMLA cream and its current uses","volume":"50","author":"Lee JJ","year":"1993","journal-title":"Br J Hosp Med"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008353"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2004\/7\/395"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0885-3924(94)90150-3"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1363.010"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000932"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15829","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T09:13:37Z","timestamp":1702804417000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.15829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,23]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/jocd.15829"],"URL":"https:\/\/doi.org\/10.1111\/jocd.15829","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,23]]},"assertion":[{"value":"2023-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}