{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:43:49Z","timestamp":1792226629121,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Melasma is a distressing disfiguring acquired pigmentary disorder especially affecting females and it is of high tendency of recurrence. Up till now, treatment of melasma is a challenging problem.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We evaluated the effectiveness of microneedling with glutathione versus microneedling alone in treatment of melasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>In this study, 29 adult females with epidermal type of melasma (confirmed with Wood's light examination) were enrolled. The affected area was subjected to microneedling using dermapen followed by application of glutathione solution on the right side only. This session was performed every 2\u2009weeks for 3\u2009months (six sessions for every patient). The response to therapy was measured using modified melasma area and severity index (m MASI) that were calculated on each side of the face (Hemi\u2010 m MASI) before treatment sessions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was statistically significant reduction in the mean of Hemi\u2010 m MASI score over the sessions on both sides of the face but the right side (microneedling with glutathione) showed more reduction and earlier response to therapy than the left side (microneedling alone). On the left side, mean of Hemi\u2010 m MASI score before and after sessions was (4.06\u2009\u00b1\u20091.91, 2.31\u2009\u00b1\u20091.450) and on the right side, it was (4.21\u2009\u00b1\u20092.08, 1.96\u2009\u00b1\u20091.30), respectively and this was statistically significant. Percentage of improvement on the left side was 46.92\u2009\u00b1\u200916.30 (%) while on the right side was 55.17\u2009\u00b1\u200915.50 (%) and this was statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Microneedling is an effective promising tool in treatment of melasma and its combination with glutathione as a whitening agent, increases and accelerates its efficacy. So, combined therapy is more preferred than monotherapy in treatment of facial melasma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15834","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T08:19:13Z","timestamp":1686730753000},"page":"3379-3386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Microneedling with glutathione versus microneedling alone in treatment of facial melasma: Split\u2010face comparative study"],"prefix":"10.1111","volume":"22","author":[{"given":"Marwa","family":"Mohamed","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of Medicine Sohag University Sohag Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yostena Mahrous Aziz","family":"beshay","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Sohag General Hospital Sohag Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan Metwally","family":"Assaf","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of Medicine Sohag University Sohag Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2021.1914313"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.33545\/26649411.2021.v4.i2a.85"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14110"},{"issue":"2","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.61148\/2766-8614\/JCCRCS\/044","article-title":"Melasma risk factor and management: a review article","volume":"3","author":"Putra Gofur N","year":"2021","journal-title":"Clin Case Rep Clin 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melasma","volume":"3","author":"Puri N","year":"2020","journal-title":"J Clinic Exper Cosme Derma"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.179088"},{"issue":"2","key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.4103\/JCAS.JCAS_182_19","article-title":"A pilot study to compare therapeutic efficacy and safety of combined treatment of skin microneedling and depigmenting cream versus depigmenting cream alone in facial melasma at tertiary care center","volume":"14","author":"Bosamiya S","year":"2021","journal-title":"J Cutan Aesthet 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