{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:36:24Z","timestamp":1781278584592,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:00:00Z","timestamp":1687132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Female androgenetic alopecia (FAGA) is a condition that affects women and involves the gradual loss of terminal hair in specific areas of the scalp. The limited treatment options for FAGA necessitate the development of new strategies. This study aimed to evaluate the potential benefit of using a combination therapy composed of autologous platelet\u2010rich plasma (PRP) and a non\u2010cross\u2010linked hyaluronic acid (HA) compound in the treatment of FAGA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective, case\u2010series study, which enrolled nine female patients with FAGA between September 2021 and December 2022. The non\u2010cross\u2010linked HA compound (Hearty\u00ae, Imeik Technology Development Co., Ltd.) and PRP were implanted into the areas of hair loss over four treatment sessions separated by 4\u2010week intervals. Patients were monitored for overall improvement in their hair loss, hair count, treatment satisfaction, and adverse events at 1, 3, and 6\u2009months follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The improvement rates, subjectively evaluated by the study physician, were 88.89% at the 1\u2010month and 100% at the 3\u2010month follow\u2010up, relative to baseline. Moreover, the quantitative evaluation results showed that the FAGA patients' hair density increased by 54.51% at the 1\u2010month and by 77.25% at the 3\u2010month follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of PRP and non\u2010cross\u2010linked HA compound appeared to be a certain positive effective procedure for FAGA without serious adverse event. We envisage that this work will contribute to the development of new treatment options for women suffering from this condition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15861","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T04:55:09Z","timestamp":1687236909000},"page":"3268-3275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy of autologous platelet\u2010rich plasma combined with a non\u2010cross\u2010linked hyaluronic acid compound in the treatment of female androgenetic alopecia: A retrospective, case\u2010series study"],"prefix":"10.1111","volume":"22","author":[{"given":"Shiwei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medical Imeik Technology Development Co., Ltd.  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