{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:35:41Z","timestamp":1788428141961,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Periorbital hyperpigmentation (POH) is a common disorder in the patients. Women are more upset with POH in compare to males. Several methods have been used to the POH, with different efficacy and adverse reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study is to evaluate the efficacy of microneedle fractional radiofrequency (MRF) in treating POH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>So, nine patients with POH and the age range of 25\u201357\u2009years, were treated by microneedle fractional radiofrequency (MRF). The outcome was evaluated via biometric assessment. The colorimeter was used to assess the skin lightness. Mexameter was used for evaluated the amount of Melanin in the periorbital skin. Cutometer was used for skin elasticity assessment. The skin ultrasound imaging system was utilized to estimate the epidermis and dermis diameter and density. Furthermore, Visioface was applied to assessed the skin color and wrinkles. Also patient's satisfaction and physician's assessment were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results displayed that the periorbital skin lightness 32.38%\u2009\u00b1\u20095.67 and elasticity of the R2: 40.29%\u2009\u00b1\u20098.18, R5: 39.03\u2009\u00b1\u20095.38 and R7: 42.03%\u2009\u00b1\u200914.16 were significantly improved after treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Also the melanin content of the skin was decreased (49.41%\u2009\u00b1\u20099.12). The skin layers were denser in the dermis and also in the epidermis (skin density: 30.21%\u2009\u00b1\u200910.16 and skin thickness: 41.12%\u2009\u00b1\u200913.21) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The results revealed the decrease in the percent change of the skin color (30.34%\u2009\u00b1\u20099.30) and wrinkle (area: 25.84%\u2009\u00b1\u20096.43 and volume: 30.66%\u2009\u00b1\u20098.12) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Similarly, the physician and patient's assessment were confirmed the obtained outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, the microneedle RF technique is practicable, effective and safe method for periorbital dark circles treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15870","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T11:30:27Z","timestamp":1686915027000},"page":"2218-2224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Microneedle fractional radiofrequency in the treatment of periorbital dark circles"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6143-8039","authenticated-orcid":false,"given":"Mohammad Ali","family":"Nilforoushzadeh","sequence":"first","affiliation":[{"name":"Skin and Stem Cell Research Center Tehran University of Medical Sciences  Tehran 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