{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:53:02Z","timestamp":1768452782950,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Observational studies have suggested that childhood body mass index (BMI) is associated with the risk of psoriasis. However, their causal relationship remains unclear. In this investigation, we aimed to determine whether an association exists between childhood BMI and psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using summary statistics for childhood BMI of European descent from publicly available GWAS meta\u2010analyses (<jats:italic>n<\/jats:italic>\u2009=\u200939\u2009620), we conducted Mendelian randomization (MR) research using the inverse variance weighting (IVW), weighted median, and MR\u2010Egger regression techniques. The outcome was a genome\u2010wide association studies (GWAS) for the self\u2010reported non\u2010cancer disease classification psoriasis in the UK Biobank population (total <jats:italic>n<\/jats:italic>\u2009=\u2009337\u2009159; case\u2009=\u20093871; control\u2009=\u2009333\u2009288).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We selected instrumental variables from 16 single\u2010molecule polymorphisms that attained genome\u2010wide significance in GWAS on childhood BMI. Using the IVW method, our findings supported a causal relationship between childhood BMI and psoriasis (beta\u2009=\u20090.003, standard error [SE]\u2009=\u20090.001, <jats:italic>p<\/jats:italic>\u2009=\u20090.006). Using MR\u2010Egger regression analysis, we evaluated the potential for directional pleiotropy to bias our results (intercept\u2009=\u20090.00039, <jats:italic>p<\/jats:italic>\u2010value\u2009=\u20090.247) and found no causal relationship between childhood BMI and psoriasis (beta\u2009=\u2009\u22120.002, SE\u2009=\u20090.004, <jats:italic>p<\/jats:italic>\u2009=\u20090.625). The weighted median method, however, provided proof of a causal relationship (beta\u2009=\u20090.003, SE\u2009=\u20090.001, <jats:italic>p<\/jats:italic>\u2009=\u20090.029). Cochran's <jats:italic>Q<\/jats:italic> test and the funnel plot revealed little proof of heterogeneity or asymmetry, indicating the lack of directional pleiotropy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>According to the findings of the MR analysis, an increased childhood BMI may be linked to a higher likelihood of psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15875","type":"journal-article","created":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T01:05:27Z","timestamp":1687655127000},"page":"3491-3499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Casual association between childhood body mass index and risk of psoriasis: A Mendelian randomization study"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9825-2676","authenticated-orcid":false,"given":"Yuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology The Fifth People's Hospital of Hainan Province  Haikou China"},{"name":"Department of Dermatology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Dermatology Hospital of Hainan Medical University  Haikou China"},{"name":"Department of Dermatology Hainan Provincial Hospital of Skin Disease  Haikou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaihe","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Fifth People's Hospital of Hainan Province  Haikou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Affiliated Hospital of Zunyi Medical University  Zunyi 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University  Zunyi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Fifth People's Hospital of Hainan Province  Haikou China"},{"name":"Department of Dermatology Hainan Provincial Hospital of Skin Disease  Haikou 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