{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:57:01Z","timestamp":1785254221254,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High\u2010functional cosmetic products combined with the concept of \u201ctreatment\u201d cosmetics are being introduced to the market. Cosmetic products containing a skin\u2010derived microbiome, a three\u2010dimensional (3D) stem cell culture medium, and low\u2010molecular\u2010weight collagen are being introduced, and these products are leading the cosmeceutical market. We aimed to confirm the potential of a 3D stem cell culture medium\u2010containing cream as a skin\u2010whitening and moisturizing product.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the enhancing effects of a cream containing 3D adipose tissue\u2010derived mesenchymal stem cell\u2010conditioned media (3D ADMSC\u2010CM) on whitening and moisturization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The inhibitory activities of tyrosinase (TYR) and melanin were confirmed using 3D ADMSC\u2010CM. Furthermore, hyaluronic acid expression in 3D ADMSC\u2010CM was verified. The clinical efficacy of the cream containing 3D ADMSC\u2010CM was established by evaluating its antioxidant properties and effects on skin tone, radiance, freckles, and moisturization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The use of 3D ADMSC\u2010CM suppressed the inhibitory effects of TYR and melanin by approximately 24% and 33%, respectively, and increased the expression of hyaluronic acid synthase. A significant difference was observed after 4\u2009weeks of using 3D ADMSC\u2010CM in the skin antioxidant evaluation. After 2 and 4\u2009weeks of use, skin tone and radiance increased and skin freckles decreased significantly. Under extremely cold and dry weather conditions, the use of the cream increased skin moisturization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The 3D ADMSC\u2010CM cream evaluated in an environment similar to the human body was found to enhance skin whitening and moisturization and can therefore be used in the skin care and cosmetic industries as a biocosmetic product.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15879","type":"journal-article","created":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T01:05:50Z","timestamp":1687655150000},"page":"3352-3361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Whitening and moisturizing enhancing effects of <scp>three\u2010dimensional<\/scp> human <scp>adipose\u2010derived<\/scp> mesenchymal stem <scp>cell\u2010conditioned medium\u2010containing<\/scp> cream"],"prefix":"10.1111","volume":"22","author":[{"given":"Kyung Hye","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Cosmetics Engineering Konkuk University  Seoul Republic of Korea"},{"name":"Cosemeceutical Team DongKoo Bio &amp; Pharma  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunray","family":"Lee","sequence":"additional","affiliation":[{"name":"Stem Cell Niche Division CEFO Research center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunghee","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Cosmetics Engineering Konkuk University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1568-1637(02)00024-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00619.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.21923"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.040667"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-11-0436"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.20402\/ajbc.2018.0258"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.14.12.7996-8006.1994"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240510027190"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2012.10.003"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.22203\/ecm.v005a03"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.6.12.1381691"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145115"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-015-0239-2"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.7.3967"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00072.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.20402\/ajbc.2018.0255"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41702-019-0053-z"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)81010-w"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12249.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000066253"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.20402\/ajbc.2017.0162"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711133372003"},{"key":"e_1_2_9_24_1","first-page":"39","volume-title":"Casarett and Doull's Toxicology","author":"Zoltan G","year":"1996"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2007.11.008"},{"issue":"2","key":"e_1_2_9_26_1","first-page":"46","article-title":"Stem cell derived cosmetic products: An overview","volume":"1","author":"Muthukumar A","year":"2016","journal-title":"Manipal J Med Sci"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T09:12:46Z","timestamp":1702804366000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.15879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,23]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/jocd.15879"],"URL":"https:\/\/doi.org\/10.1111\/jocd.15879","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,23]]},"assertion":[{"value":"2022-11-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}