{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:46:04Z","timestamp":1776185164486,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013671","name":"Sun Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013671","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Squamous cell carcinoma (SCC) is the second most common cutaneous malignancy, after basal cell carcinoma (BCC). Photodynamic therapy (PDT) involves converting a photosensitizer to reactive oxygen intermediates, which preferentially bind to hyperproliferative tissue. The most commonly used photosensitizers are methyl aminolevulinate and aminolevulinic acid (ALA). Presently, ALA\u2010PDT is approved in the US and Canada for the treatment of actinic keratoses on the face, scalp, and upper extremities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This cohort study evaluated the safety, tolerability, and efficacy of aminolevulinic acid, pulsed dye laser, and photodynamic therapy (ALA\u2010PDL\u2010PDT) for treatment of facial cutaneous squamous cell carcinoma in situ (isSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty adult patients with biopsy\u2010confirmed isSCC on the face were recruited. Only lesions 0.4\u20131.3\u2009cm in diameter were included. Patients underwent two treatments with ALA\u2010PDL\u2010PDT spaced 30\u2009days apart. The isSCC lesion was then excised 4\u20136\u2009weeks following the second treatment for histopathological assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No residual isSCC was detected in 17\/20 (85%) patients. Two of the patients with residual isSCC had skip lesions present that explained the treatment failure. Excluding the patients with skip lesions, the posttreatment histological clearance rate was 17\/18 (94%). Minimal side effects were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>Our study was limited by small sample size and lack of long\u2010term recurrence data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The ALA\u2010PDL\u2010PDT protocol is a safe and well\u2010tolerated treatment option for isSCC on the face, providing excellent cosmetic and functional results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15886","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T08:02:02Z","timestamp":1687852922000},"page":"2471-2475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Evaluating the safety and efficacy of aminolevulinic acid 20% topical solution activated by pulsed dye laser and blue light in the treatment of facial cutaneous squamous cell carcinoma in situ"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8978-7932","authenticated-orcid":false,"given":"Mark S.","family":"Nestor","sequence":"first","affiliation":[{"name":"Center for Clinical and Cosmetic Research  Aventura Florida USA"},{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine  Miami Florida USA"},{"name":"Department of Surgery, Division of Plastic Surgery University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haowei","family":"Han","sequence":"additional","affiliation":[{"name":"Center for Clinical and Cosmetic Research  Aventura Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca M.","family":"Ceci","sequence":"additional","affiliation":[{"name":"Center for Clinical and Cosmetic Research  Aventura Florida 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