{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T17:56:52Z","timestamp":1781978212302,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hypertrophic scar (HS) that can lead to defects in appearance and function is often characterized by uncontrolled fibroblast proliferation and excessive inflammation. Curcumin has been shown to have anti\u2010inflammatory and anti\u2010oxidative effects and to play an anti\u2010fibrotic role by interfering transforming growth factor\u2010\u03b21 (TGF\u2010\u03b21)\/Smads signaling pathways.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To study the effect and mechanism of curcumin on HS from the perspective of fibroblast activity and inflammation regulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cell proliferation, migration and the expression of \u03b1\u2010smooth muscle actin (\u03b1\u2010SMA) of TGF\u2010\u03b21\u2010induced human dermal fibroblasts (HDFs) treated by curcumin were evaluated using Cell Counting Kit\u20108 assay, 5\u2010ethynyl\u20102\u2032\u2010deoxyuridine staining, Transwell assay, Western blotting and immunofluorescence, respectively. The expression of TGF\u2010\u03b21\/Smad3 pathway\u2010related molecules (TGF\u2010\u03b21, TGF\u03b2\u2010R1\/2, p\u2010Smad3, Smad4) was detected by Western blotting. In a rabbit ear model, hematoxylin and eosin and Masson's staining were conducted to assess scar elevation and collagen deposition, and immunohistochemistry was performed to detect the activation of fibroblasts and infiltration of inflammatory cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Curcumin inhibited proliferation, migration and \u03b1\u2010SMA expression of HDFs in a dose\u2010dependent manner. Curcumin (25\u2009\u03bcm\u2009mol\/L) did not regulate the expression of endogenous TGF\u2010\u03b21, but suppressed Smad3 phosphorylation and nuclear translocation, leading to lower \u03b1\u2010SMA expression. Curcumin also reduced hypertrophic scarring of rabbit ear, accompanied by the inhibited TGF\u2010\u03b21\/Smad3 pathway, inflammatory infiltration and M2 macrophage polarization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Curcumin plays an anti\u2010scar role through regulating fibroblast activation and tissue inflammation. Our findings provide scientific reference for the clinical use of curcumin in the treatment of HS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15905","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T04:41:07Z","timestamp":1688445667000},"page":"227-235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Curcumin alleviates hypertrophic scarring by inhibiting fibroblast activation and regulating tissue inflammation"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7196-2640","authenticated-orcid":false,"given":"Huanhuan","family":"Fei","sequence":"first","affiliation":[{"name":"Department of Pathology Huzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2008-4160","authenticated-orcid":false,"given":"Yao","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Huzhou Central Hospital Affiliated to Huzhou University  Huzhou China"},{"name":"Department of Plastic Surgery Jiahui Medical Beauty Clinic Co.Ltd  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3512-898X","authenticated-orcid":false,"given":"Tianyun","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Pathology Huzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5389-4576","authenticated-orcid":false,"given":"Ying","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Huzhou Central Hospital Affiliated to Huzhou University  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6005-8077","authenticated-orcid":false,"given":"Yun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pathology Huzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(07)57004-X"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2008.06.020"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871530311006040320"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2807"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23511"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1716"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6976"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-010-1075-y"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1667\/RADE-20-00239.1"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/15376516.2020.1801926"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.17.5353"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.09.010"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2007.00224.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14108"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-021-00514-y"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2003-0063OC"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e05-02-0149"},{"key":"e_1_2_12_19_1","first-page":"1189","article-title":"Inhibitory effect of TGF\u2010\u03b2 peptide antagonist on the fibrotic phenotype of human hypertrophic scar fibroblasts","volume":"54","author":"Wang X","year":"2016","journal-title":"Pharm Biol"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20051119"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071545"},{"key":"e_1_2_12_22_1","article-title":"The role of macrophages in the formation of hypertrophic scars and keloids. 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