{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:50:35Z","timestamp":1789728635547,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T00:00:00Z","timestamp":1688688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fractional carbon dioxide (CO<jats:sub>2<\/jats:sub>) laser resurfacing is used successfully for facial rejuvenation. Post procedure skincare is a variable that influences downtime caused by pain\/tenderness, erythema, crusting, and bruising.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The primary objective of this pilot study was to demonstrate the benefits of human platelet extract (HPE) (plated)\u2122 CALM Serum, a new topical cosmetic product, following fractionated CO<jats:sub>2<\/jats:sub> ablative laser resurfacing treatment to the entire face versus standard of care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a single\u2010center, randomized, evaluator\u2010blinded pilot study, a total of 18 subjects were randomized into two groups, CO<jats:sub>2<\/jats:sub> facial resurfacing followed by post\u2010procedural standard of care (Stratacel silicone gel) or CO<jats:sub>2<\/jats:sub> facial resurfacing with the addition of HPE renewosomes in the CALM Serum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CALM Serum demonstrated statistically significant less crusting at Day 10 compared to the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.0193) with less downtime in the first 14\u2009days (<jats:italic>p<\/jats:italic>\u2009=\u20090.03). Subjects treated with CALM Serum had statistically significant brighter appearing skin at 14\u2009days (<jats:italic>p<\/jats:italic>\u2009=\u20090.007) and more youthful looking skin on Days 14 and 30 (<jats:italic>p<\/jats:italic>\u2009=\u20090.003 and 0.04, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates that Renewosome\u2122 technology provides statistically significant post\u2010laser clinical recovery over silicone gel for reducing crusting, and downtime. Subjects reported less diary days of symptoms of pain\/tenderness, redness, crusting\/flaking, bruising, and itching in the first 14\u2009days compared to the control group. CALM also demonstrated statistically significant improvements in brighter and more youthful appearing skin. CALM is safe and well tolerated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15914","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T11:55:20Z","timestamp":1688730920000},"page":"2464-2470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Safety and efficacy of human platelet extract in skin recovery after fractional CO<sub>2<\/sub> laser resurfacing of the face: A\u00a0randomized, controlled, evaluator\u2010blinded pilot study"],"prefix":"10.1111","volume":"22","author":[{"given":"Steven","family":"Dayan","sequence":"first","affiliation":[{"name":"DeNova Research  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5088-7995","authenticated-orcid":false,"given":"Nimit","family":"Gandhi","sequence":"additional","affiliation":[{"name":"DeNova Research  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Wilson","sequence":"additional","affiliation":[{"name":"University of Illinois  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eljona","family":"Kola","sequence":"additional","affiliation":[{"name":"DeNova Research  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Eaton","family":"Jankov","sequence":"additional","affiliation":[{"name":"UltaMed Corporation  Fort Lauderdale Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Copeland","sequence":"additional","affiliation":[{"name":"Boulder Biostatistics  Steamboat Springs Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5882-709X","authenticated-orcid":false,"given":"Chris","family":"Paradise","sequence":"additional","affiliation":[{"name":"Rion Aesthetics  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atta","family":"Behfar","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-021-02288-2"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.16"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-022-02892-w"},{"key":"e_1_2_12_5_1","unstructured":"American Society of Plastic Surgeons.2020 plastic surgery statistics report. 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