{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:52:31Z","timestamp":1790959951879,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the efficacy and safety of 1565\u2010nm nonablative fractional laser (NAFL) combined with mucopolysaccharide polysulfate (MPS) cream in the treatment of erythematous acne scars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 28 subjects with erythematous acne scars from June 2021 to April 2022 were enrolled. One side of each subject's face was randomly assigned to be treated with 1565\u2010nm NAFL (at 2 sessions with four\u2010week intervals) combined with MPS cream (twice daily) for 8\u2009weeks, and the other side with 1565\u2010nm NAFL combined with placebo cream. CBS\u00ae images and parameters, dermoscopic images and the quantitative data processed by ImageJ software, and quantitative global scarring grading system (GSS) score were obtained at baseline and after treatment. Subjects' satisfaction assessment was performed after treatment. Adverse events were recorded during treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In CBS\u00ae parameters, the red area, red area concentration, and smoothness were improved more significantly on the 1565\u2010nm NAFL combined with MPS cream side than on the 1565\u2010nm NAFL combined with placebo cream side after treatment (<jats:italic>p<\/jats:italic>\u2009=\u20090.015, <jats:italic>p<\/jats:italic>\u2009=\u20090.013, and <jats:italic>p<\/jats:italic>\u2009=\u20090.021). For dermoscopy, both scar area and scar redness achieved a significantly greater percentage of improvement on the side of 1565\u2010nm NAFL combined with MPS cream than the side of 1565\u2010nm NAFL combined with placebo cream after treatment (<jats:italic>p<\/jats:italic>\u2009=\u20090.005 and <jats:italic>p<\/jats:italic>\u2009=\u20090.041). The reduction of quantitative GSS score and Subjects' satisfaction assessment were similarly superior on the 1565\u2010nm NAFL combined with MPS cream side. Temporary erythema was experienced by all subjects after each 1565\u2010nm NAFL treatment. No subject reported intolerance or allergy to the cream during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combined application of 1565\u2010nm NAFL and MPS cream could be an effective and safe treatment for erythematous acne scars. ImageJ software enables quantitative evaluation of dermoscopic images of acne scars.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15935","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T05:34:30Z","timestamp":1689744870000},"page":"3008-3016","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy and safety of 1565\u2010nm nonablative fractional laser combined with mucopolysaccharide polysulfate cream for erythematous acne scars"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2924-6034","authenticated-orcid":false,"given":"Xiaoli","family":"Ning","sequence":"first","affiliation":[{"name":"Graduate School of Capital Medical University  Beijing China"},{"name":"Department of Dermatology China\u2010Japan Friendship Hospital  Beijing 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