{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T02:36:16Z","timestamp":1788662176018,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The most visible sign of facial aging is often seen in the periocular area. However, periocular rejuvenation remains challenging due to the particularity of periocular anatomic locations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to evaluate the efficacy and safety of the fractional\u2010ablative CO<jats:sub>2<\/jats:sub> laser\u2010facilitated recombinant human collagen permeation in periocular rejuvenation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>This 3\u2010month prospective single\u2010blinded and self\u2010controlled trial enrolled 26 patients with periocular aging who underwent the treatments of fractional\u2010ablative CO<jats:sub>2<\/jats:sub> laser along with laser\u2010facilitated recombinant human collagen permeation. Following the treatments, the patients were quantitatively assessed by various periocular skin aging indices before and after the treatment and monitored for any related adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients showed significant improvements with the periocular skin aging indices 3\u2009months after the treatments, which were detailed with a 47.3% decrease in lower eyelid skin rhytids, a 41.4% decrease in the lower eyelid skin texture, a 35.0% decrease in the static crow's feet, a 29.3% decrease in the amount of upper eyelid laxity, and a 20.2% increase in the MRD1 as compared with baseline (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Moreover, total skin thickness under ultrasound was increased in both upper and lower eyelids (5.6% and 3.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05, respectively). Moreover, six patients (23.1%, 6\/26) had erythema for 2\u2009weeks, and two (2\/26, 7.7%) had mild hyperpigmentation for 3\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fractional\u2010ablative CO<jats:sub>2<\/jats:sub> laser combined with laser\u2010facilitated recombinant human collagen permeation can be a safe and effective treatment for periocular rejuvenation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15942","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T11:31:22Z","timestamp":1690889482000},"page":"124-133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Combination of fractional carbon dioxide laser with recombinant human collagen in periocular skin rejuvenation"],"prefix":"10.1111","volume":"23","author":[{"given":"Hui\u2010Hui","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Dermatology The East Division of The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Qing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound The East Division of The First Affiliated Hospital, Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan\u2010Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The East Division of The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u2010Li","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Dermatology The East Division of The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou 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