{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:47:17Z","timestamp":1790938037869,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,13]],"date-time":"2023-08-13T00:00:00Z","timestamp":1691884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Androgenetic alopecia (AGA) is the most common type of hair loss in men, and several treatment options have been proposed for it. Fractional ablative erbium YAG laser can promote hair growth through trans\u2010epidermal drug delivery and the thermal stimulation of hair follicles; this study therefore aims to evaluate minoxidil alone and in combination with fractional ablative erbium YAG laser in male patients with AGA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was performed on 30 male patients with moderate to severe AGA. Patients were equally randomized into two groups, and the intervention group was treated with 1\u2009mL of topical 5% minoxidil twice daily and six sessions of 2940\u2010nm ablative fractional erbium YAG laser, and the control group received topical 5% minoxidil alone. The assessment entailed photography, dermoscopy, and patient satisfaction based on a 7\u2010point grading scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both groups showed statistically significant improvements in terms of patient satisfaction, photography, and dermoscopy scores. The group receiving a combination of laser and minoxidil treatment obtained a higher dermoscopy score than the patients receiving minoxidil alone (<jats:italic>p<\/jats:italic>\u2010value\u2009=\u20090.016). Nonetheless, there was no difference between the two groups in terms of the photography score (<jats:italic>p<\/jats:italic>\u2010value\u2009=\u20090.13).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Laser treatment can stimulate the hair follicles and also enhance the dermal delivery of minoxidil, which was found to be associated with slightly better outcomes in this study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15955","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T06:29:00Z","timestamp":1691994540000},"page":"2737-2743","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Topical 5% minoxidil versus combined erbium YAG laser and topical 5% minoxidil in androgenetic alopecia: A randomized controlled trial"],"prefix":"10.1111","volume":"22","author":[{"given":"Fatemeh","family":"Mokhtari","sequence":"first","affiliation":[{"name":"Department of Dermatology, Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Zavare","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0206-0352","authenticated-orcid":false,"given":"Fariba","family":"Iraji","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13122"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-019-02783-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/der2.58"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000002157"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics8010025"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13976"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15328"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.5070\/D3252042885"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2232-8"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14370"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2017.1418516"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-020-03046-7"},{"issue":"1","key":"e_1_2_10_14_1","first-page":"267","article-title":"Oral pulse betamethasone, methotrexate, and combination therapy to treat severe alopecia areata: a randomized, double\u2010blind, placebo\u2010controlled, clinical trial","volume":"20","author":"Asilian A","year":"2021","journal-title":"Iran J Pharm Res"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656561003752730"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.02.054"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.15171\/jlms.2020.06"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-020-00478-5"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2306-7"},{"issue":"4","key":"e_1_2_10_20_1","first-page":"179","article-title":"Androgenetic alopecia\u2010current status","volume":"50","author":"Thomas J","year":"2005","journal-title":"Indian J Dermatol"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12686"},{"issue":"3","key":"e_1_2_10_22_1","first-page":"185","article-title":"Topical minoxidil: systematic review and meta\u2010analysis of its efficacy in androgenetic alopecia","volume":"13","author":"Gupta AK","year":"2015","journal-title":"Skinmed"},{"issue":"11","key":"e_1_2_10_23_1","first-page":"20883","article-title":"Erbium: YAG laser (2,940 nm) treatment stimulates hair growth through upregulating Wnt 10b and \u03b2\u2010catenin expression in C57BL\/6 mice","volume":"8","author":"Ke J","year":"2015","journal-title":"Int J Clin Exp 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