{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:28:59Z","timestamp":1792009739123,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ultraviolet light, visible light, infrared light, and pollution are a few examples of environmental factors that exacerbate the formation of reactive oxygen species (ROS) that cause damage to skin cells' DNA, proteins, and lipids. By supplementing the skin with antioxidants, we can help neutralize ROS formed by these extrinsic factors before they can damage the skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This prospective open\u2010label study explores the safety and efficacy of this novel topical formulation of antioxidants (vitamin C, astaxanthin, fermented turmeric, and vitamin E) designed to fight free radical damage and improve overall skin quality, as well as the appearance of fine lines, wrinkles, radiance, and hyperpigmentation of the skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>This single\u2010center clinical study evaluated the efficacy of twice\u2010daily application of the test article (Asta C\u2122 Vitamin C Age Defense Serum, Dr. Whitney Bowe Beauty) in 32 subjects for 12\u2009weeks. Healthy female subjects aged 35\u201360 with mild to moderate fine lines, wrinkles, and hyperpigmentation\/uneven skin tone were enrolled in this study. Fitzpatrick skin types I\u2013VI, all skin types (dry, normal, combination, oily), and subjects with sensitive skin were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All subjects demonstrated improvement in overall skin quality (face, neck, and chest) by the end of the 12\u2010week study period. One hundred percent of subjects demonstrated improvement in the appearance of fine lines at Week 12.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, the current clinical study demonstrates that Asta C\u2122 is safe, well\u2010tolerated, and effective in improving overall skin quality, as well as the appearance of fine lines, wrinkles, radiance, and hyperpigmentation of the skin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15967","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T04:55:18Z","timestamp":1692766518000},"page":"3088-3094","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A clinical evaluation of the efficacy and tolerability of a novel topical antioxidant formulation featuring vitamin C, astaxanthin, and fermented turmeric"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5189-6677","authenticated-orcid":false,"given":"Hailey","family":"Konisky","sequence":"first","affiliation":[{"name":"Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney P.","family":"Bowe","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York City New York USA"},{"name":"Dr. Whitney Bowe Beauty  Greenwich Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pada","family":"Yang","sequence":"additional","affiliation":[{"name":"Dr. Whitney Bowe Beauty  Greenwich Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kseniya","family":"Kobets","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine  Bronx New York 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