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Aging is affected by intrinsic factors (e.g., genetics, race\/ethnicity, anatomical variations) and extrinsic factors (e.g., lifestyle, environment).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To provide a general overview of minimally invasive injectable procedures for facial beautification and rejuvenation to meet the aesthetic goals of patients across their lifespan, organized by decade.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case study review describes aesthetic considerations of females in their third to sixth decade of life (i.e., 20\u201360\u2009years of age or beyond). Each case study reports the treatments, specifically botulinum toxin type A and soft tissue fillers, used to address aesthetic concerns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Signs of aging, as well as aesthetic goals and motivations, vary by age groups, cultures, and races\/ethnicities. However, there are overarching themes that are associated with each decade of life, such as changes in overall facial shape and specific facial regions, which can be used as a starting point for aesthetic treatment planning. Appropriate patient selection, thorough aesthetic evaluation, product knowledge, and injection technique, as well as good physician\u2010patient communication, are essential for optimal treatment outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nonsurgical facial injectable treatments can successfully enhance and rejuvenate facial features across different age ranges. A comprehensive understanding of facial aging and the aesthetic considerations of patients by the decade contributes to optimal treatment planning and maintenance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15968","type":"journal-article","created":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T08:29:48Z","timestamp":1693038588000},"page":"2889-2901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Decades of beauty: Achieving aesthetic goals throughout the lifespan"],"prefix":"10.1111","volume":"22","author":[{"given":"Joel L.","family":"Cohen","sequence":"first","affiliation":[{"name":"AboutSkin Dermatology and DermSurgery  Greenwood Village Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4089-9690","authenticated-orcid":false,"given":"Greg J.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Adjunct Professor of Dermatology 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