{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:46:13Z","timestamp":1788306373598,"version":"build-2803163510"},"reference-count":11,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T00:00:00Z","timestamp":1693008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n A previous injection algorithm termed the \u201cToxin Lift\u201d was recently introduced and described volume increases in the midface following neuromodulator treatments of the jawline. Increase in midfacial volume due to soft tissue repositioning could also affect the severity of infraorbital hollows.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n The objective is therefore to evaluate whether the severity of infraorbital hollows can be improved by injecting neuromodulators in the supra\u2010mandibular segment of the platysma.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n A total of 35 volunteers (11 males\/24 females) with a mean age of 39.8 (9.6) years and a mean BMI of 25.2 (5.2) kg\/m\n 2<\/jats:sup>\n were investigated. Bilateral infraorbital regions were evaluated via clinical assessment and semi\u2010quantitative 3D imaging. The applied injection technique targeted the platysma via four injection points administering 5 I.U. per injection point resulting in a total of 20 I.U. per facial side.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Volume increase of the infraorbital region was 0.13\u2009cc at 15\u2009days (\n p<\/jats:italic>\n \u2009=\u20090.001) and was 0.02\u2009cc at 30\u2009days (\n p<\/jats:italic>\n \u2009=\u20090.452) whereas the skin displacement in cranial direction was 0.54\u2009mm at 15\u2009days (\n p<\/jats:italic>\n \u2009<\u20090.001) and was 0.31\u2009mm at 30\u2009days (\n p<\/jats:italic>\n \u2009<\u20090.001). Clinical evaluation revealed a highly statistically significant improvement of the tear trough, palpaebromalar groove, and of the lid\u2010cheek junction when compared to baseline with all p\u2009<\u20090.001.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The results of this clinical prospective interventional analysis revealed that the \u201cToxin Lift\u201d injection technique is capable to improve the clinical appearance of infraorbital hollows. The effects can be explained by the concepts of facial biomechanics.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.15970","type":"journal-article","created":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T03:39:20Z","timestamp":1693021160000},"page":"2950-2956","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["How to improve infraorbital hollows with neuromodulators\u2013A clinical prospective interventional study about the application of facial biomechanics"],"prefix":"10.1111","volume":"22","author":[{"given":"Marcelo","family":"Germani","sequence":"first","affiliation":[{"name":"Private Office Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia C. M. S.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Private Office Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1134-8542","authenticated-orcid":false,"given":"Victor R. M.","family":"Munoz\u2010Lora","sequence":"additional","affiliation":[{"name":"Let's HOF Academy Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Rog\u00e9rio","sequence":"additional","affiliation":[{"name":"Let's HOF Academy Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Moelhoff","sequence":"additional","affiliation":[{"name":"Department for Hand, Plastic and Aesthetic Surgery Ludwig\u2013Maximilian University Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Freytag","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Gemeinschaftsklinikum Havelh\u00f6he Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy B.","family":"Green","sequence":"additional","affiliation":[{"name":"Skin Associates of South Florida and Skin Research Institute Coral Gables Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4892-2376","authenticated-orcid":false,"given":"Michael","family":"Alfertshofer","sequence":"additional","affiliation":[{"name":"Department for Hand, Plastic and Aesthetic Surgery Ludwig\u2013Maximilian University Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Davidovic","sequence":"additional","affiliation":[{"name":"Department of Radiology & Medical School University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7210-6566","authenticated-orcid":false,"given":"Sebastian","family":"Cotofana","sequence":"additional","affiliation":[{"name":"Department of Dermatology Erasmus Hospital Rotterdam The Netherlands"},{"name":"Centre for Cutaneous Research Blizard Institute, Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2022.01.001"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjac090"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4322\/bds.2022.e3411"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000848"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02251.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764170701545657"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000003429"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjy286"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002236"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/794682"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/asjof\/ojac034"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T22:31:15Z","timestamp":1698013875000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.15970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,26]]},"references-count":11,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/jocd.15970"],"URL":"https:\/\/doi.org\/10.1111\/jocd.15970","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,26]]},"assertion":[{"value":"2023-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}