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Interleukin\u201017A (IL\u201017A) is the major effect factor in the pathogenesis of psoriasis. Our results showed that IL\u201017A can promote angiogenesis and cause endothelial cell inflammation. Autophagy plays an important role not only in regulating inflammation, but also in regulating angiogenesis. Whether angiogenesis in psoriasis is related to autophagy remains unclear. In this study, we treated human umbilical vein endothelial cells (HUVECs) with IL\u201017A to simulate increased angiogenesis to study whether increased angiogenesis in psoriasis is related to autophagy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Our results showed that treatment of HUVECs with IL\u201017A significantly increased angiogenesis and expression levels of mRNA for multiple proinflammatory cytokines (CCL20, IL\u20108, CCL2, IL\u20106, and IL\u20101\u03b2) and, while decreasing intracellular levels of nitric oxide (NO) and NO synthase (NOS) activity. Moreover, IL\u201017A inhibited autophagy as shown that IL\u201017A significantly increased expression levels of LC3II and p62 proteins. Induction of autophagy ameliorated IL\u201017A\u2010mediated inflammatory response and inhibited angiogenesis, accompanied by increased p\u2010AMPK\u03b1(Thr172) and p\u2010ULK1(Ser555) expression, and decreased p\u2010mTOR(Ser2448) and p\u2010ULK1(Ser757) expression. Furthermore, inhibition of either AMPK or lysosomal acidification completely overrode autophagy\u2010induced changes in angiogenesis and NOS activity. Finally, induction of autophagy decreased apoptosis and caspase\u20103 activity in IL\u201017A\u2010treated HUVECs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results showed that IL\u201017A is involved in angiogenesis and inflammatory response by inhibiting autophagy through AMPK signaling pathway, suggesting that autophagy may be a new therapeutic target for psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15975","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T05:14:39Z","timestamp":1693199679000},"page":"326-338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["IL\u201017A is involved in the hyperplasia of blood vessels in local lesions of psoriasis by inhibiting autophagy"],"prefix":"10.1111","volume":"23","author":[{"given":"Juanjuan","family":"Wang","sequence":"first","affiliation":[{"name":"Shanxi Key Laboratory of Stem Cells 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