{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T21:09:32Z","timestamp":1785186572041,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Minoxidil is the only US FDA approved topical drug for the treatment of androgenetic alopecia (AGA). Minoxidil is effective in hair re\u2010growth in 30%\u201340% of patients and 50% of males. To exert its hair growing effect, minoxidil must be sulfonated in the scalp by the minoxidil sulfotransferase enzyme (SULT1A1). Low scalp SULT1A1 correlates with lack of minoxidil response; thus, supplementing the scalp SULT1A1 with naturally occurring minoxidil sulfotransferase enzymes could potentially improve treatment outcomes in AGA patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we set to characterize SULT1A1 activity in various plants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From the 10 common botanical extracts we have studied, seven exhibited significant activity toward minoxidil as a substrate; thus, providing a potential novel paradigm to increase minoxidil response with natural supplements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To the best of our knowledge, this is the first study to characterize naturally occurring minoxidil sulfotransferase enzymes in plants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15980","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T11:23:42Z","timestamp":1693221822000},"page":"339-343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Minoxidil sulfotransferase enzymatical activity in plants: A novel paradigm in increasing minoxidil response in androgenetic alopecia"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7745-9993","authenticated-orcid":false,"given":"Nina","family":"Mehta","sequence":"first","affiliation":[{"name":"University of North Carolina School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Huang","sequence":"additional","affiliation":[{"name":"DA Labs, Inc.  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachita","family":"Dhura","sequence":"additional","affiliation":[{"name":"Department of Dermatology LTM Medical College and Hospital Sion  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4636-4489","authenticated-orcid":false,"given":"Carlos","family":"Wambier","sequence":"additional","affiliation":[{"name":"Department of Dermatology Alpert Medical School of Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"do Nascimento\u00a0Fonesca","sequence":"additional","affiliation":[{"name":"College of Medicine Nilton Lins University  Manaus Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Little","sequence":"additional","affiliation":[{"name":"DA Labs, Inc.  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8190-2289","authenticated-orcid":false,"given":"Andy","family":"Goren","sequence":"additional","affiliation":[{"name":"University of Rome (\u201cG. Marconi\u201d)  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S214907"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.02.024"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14071360"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.12.053"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/187221312800166859"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13195"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12164"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12111"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00425-022-03902-6"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.19.01447"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5768"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-012-5944-4"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15980","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T01:36:47Z","timestamp":1707442607000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.15980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,28]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/jocd.15980"],"URL":"https:\/\/doi.org\/10.1111\/jocd.15980","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,28]]},"assertion":[{"value":"2023-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}