{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T08:49:32Z","timestamp":1747817372867,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T00:00:00Z","timestamp":1701475200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is an increasing demand for facial skin rejuvenation. Specialized aesthetic skincare treatments may be one of the first steps to help prevent or treat facial signs of aging. This article discusses aesthetic skin care for facial skin rejuvenation, particularly data on two creams containing <jats:italic>Macrocystis pyrifera<\/jats:italic> ferment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The authors convened a dermatology advisory board to discuss challenges and practices in using skincare for facial rejuvenation, combining their expert opinion and experience on facial rejuvenation with preclinical and clinical data on two creams containing <jats:italic>Macrocystis pyrifera<\/jats:italic> ferment and a review of the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Preclinical and clinical studies on <jats:italic>Macrocystis pyrifera<\/jats:italic> ferment and two creams containing the ferment exhibit anti\u2010inflammatory, anti\u2010aging, and healing properties. In preclinical studies, the ferment demonstrated collagen type I enhancing properties in ex vivo skin models, and skin cells treated with the ferment migrated faster than untreated cells in the in vitro study. In clinical studies measuring visible anti\u2010inflammatory activity, the ferment alone and the ferment\u2010containing products significantly decreased erythema, and in anti\u2010aging studies, they improved visible skin aging parameters. Finally, in clinical studies on the stratum corneum, the two creams increased moisture levels and decreased transepidermal water loss (TEWL), reflecting healing by enhancing barrier strength and recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The <jats:italic>Macrocystis pyrifera<\/jats:italic> ferment and creams containing the ferment are effective skin care treatment products to decrease the visible effects of inflammation and signs of aging while promoting healing by enhancing barrier resilience and recovery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15986","type":"journal-article","created":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T19:13:05Z","timestamp":1701544385000},"page":"3313-3319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>Macrocystis pyrifera<\/i> ferment\u2010containing creams for optimizing facial skin rejuvenation"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5183-5433","authenticated-orcid":false,"given":"Michael","family":"Gold","sequence":"first","affiliation":[{"name":"Gold Skin Care Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon\u2010Soo Cindy","family":"Bae","sequence":"additional","affiliation":[{"name":"Laser &amp; Skin Surgery Center of New York  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8950-439X","authenticated-orcid":false,"given":"David J.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Schweiger Dermatology Group  Hackensack New Jersey USA"},{"name":"Icahn School of Medicine at Mt. Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumayah","family":"Jamal","sequence":"additional","affiliation":[{"name":"Schweiger Dermatology Group  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy B.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Lewis Dermatology &amp; Associates  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shari","family":"Marchbein","sequence":"additional","affiliation":[{"name":"NYU School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Ros","sequence":"additional","affiliation":[{"name":"Dermatology Institute and Laser Center  Clifton New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uma","family":"Santhanam","sequence":"additional","affiliation":[{"name":"The Estee Lauder Companies  Melville New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"DiNatale","sequence":"additional","affiliation":[{"name":"The Estee Lauder Companies  Melville New York USA"},{"name":"La Mer, Max Huber Research Labs  Melville New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Emmetsberger","sequence":"additional","affiliation":[{"name":"The Estee Lauder Companies  Melville New York USA"},{"name":"La Mer, Max Huber Research Labs  Melville New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12122142"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.15171\/apb.2019.042"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12817"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics7020033"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14981"},{"issue":"5","key":"e_1_2_10_7_1","first-page":"14","article-title":"A randomized, double\u2010blind, placebo\u2010controlled clinical study investigating the efficacy and tolerability of a peptide serum targeting expression lines","volume":"14","author":"Nguyen TQ","year":"2021","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13037"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-022-00839-2"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-022-03454-2"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.892505"},{"volume-title":"Facial skin rejuvenation with two creams containing Macrocystis pyrifera ferment","year":"2023","author":"Gold M","key":"e_1_2_10_12_1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.05.447"},{"key":"e_1_2_10_14_1","unstructured":"\"Cosmeceutical\".US Food & Drug Administration. Updated February 252022Accessed March 9 2023 https:\/\/www.fda.gov\/cosmetics\/cosmetics\u2010labeling\u2010claims\/cosmeceutical#:~:text=The%20term%20%22cosmeceutical%22%20has%20no drug%2C%20a%20cosmetic%20or%20both"},{"volume-title":"Cosmeceuticals","year":"2022","author":"Pandey A","key":"e_1_2_10_15_1"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T09:13:16Z","timestamp":1702804396000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.15986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/jocd.15986"],"URL":"https:\/\/doi.org\/10.1111\/jocd.15986","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"2023-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}