{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:09:40Z","timestamp":1767913780230,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T00:00:00Z","timestamp":1694304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Frontal fibrosing alopecia (FFA) is a cicatricial alopecia with rapid epidemic growth. However, there is no agreement on the best therapeutic approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare the therapeutic effects of finasteride as a first\u2010line systemic treatment of FFA versus hydroxychloroquine as a relatively safe and effective immunosuppressive drug.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010four female FFA patients were randomly assigned to receive either 400\u2009mg\/day of hydroxychloroquine or 2.5\u2009mg\/day of finasteride for 6 months. Topical treatments in both groups include pimecrolimus, mometasone, and minoxidil. Treatment efficacy was evaluated using the Frontal Fibrosing Alopecia Severity Score (FFASS), photography, and trichoscopy after 3 and 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both the finasteride and hydroxychloroquine groups showed significant improvements in FFASS and trichoscopic scores (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). However, there was no significant difference between the two groups during the study. Photographic assessment showed that more than 60% of patients in both groups had improved without statistically significant differences between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both finasteride and hydroxychloroquine are equally effective, safe, and well\u2010tolerable for treating FFA patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15993","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T04:24:46Z","timestamp":1694406286000},"page":"576-584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical effectiveness of finasteride versus hydroxychloroquine in the treatment of frontal fibrosing alopecia: A randomized controlled trial"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5058-9050","authenticated-orcid":false,"given":"Mina","family":"Saber","sequence":"first","affiliation":[{"name":"Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, School of Medicine Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Farokhshahi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, School of Medicine Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0618-5512","authenticated-orcid":false,"given":"Farahnaz","family":"Fatemi\u00a0Naeini","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, School of Medicine Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8492-2410","authenticated-orcid":false,"given":"Fatemeh","family":"Mohaghegh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, School of Medicine Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Asilian","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, School of Medicine Isfahan University of Medical Sciences  Isfahan 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