{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:45:49Z","timestamp":1788439549394,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010inflammatory hyperpigmentation (PIH) is a common complication after laser surgeries. Recent studies applied epidermal growth factor (EGF) on the lasered area after laser surgery to decrease the incidence of PIH with controversial results. Therefore, a comprehensive literature review of randomized controlled trials (RCTs) was conducted to investigate the issue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two reviewers independently searched the literatures, extracted, and analyzed the data. A total of seven RCTs involving 169 patients were included to evaluate the efficacy of EGF on recovery and PIH prevention after laser surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results show that the incidence of PIH in the EGF group was relatively lower than that in the control group, although the difference was not statistically significant (OR 0.64, 95% CI 0.33\u2009~\u20091.25, <jats:italic>p<\/jats:italic>\u2009=\u20090.19). However, the EGF groups had a significant decrease in melanin index (MI) scores at the 1st month after the laser surgery when compared to the control groups (SMD \u22121.57, 95% CI \u22122.83\u2009~\u2009\u22120.31, <jats:italic>p<\/jats:italic>\u2009=\u20090.01). In addition, the patients on the EGF side rated significantly higher satisfactory scores (SMD 0.49, 95% CI 0.22\u2009~\u20090.76, <jats:italic>p<\/jats:italic>\u2009=\u20090.0004). There was no significant difference as regard to changes in MI at the 2nd week and 2nd month, erythema index (EI), and trans\u2010epidermal water loss (TEWL) at days 3 and 7 after laser therapy, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current meta\u2010analysis found a limited temporary inhibitory effect of EGF\u2010containing topical products on PIH with no significant effect on reducing post\u2010laser erythema or promoting epidermal barrier repair. More studies are needed in the future due to the small sample size and marked intergroup heterogeneities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16007","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T05:56:01Z","timestamp":1697694961000},"page":"382-390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The role of epidermal growth <scp>factor\u2010containing<\/scp> topical products on recovery and post\u2010inflammatory hyperpigmentation prevention after laser surgeries: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"23","author":[{"given":"Jieya","family":"Ying","sequence":"first","affiliation":[{"name":"Department of Dermatology, Hangzhou Third People's Hospital Affiliated Hangzhou Dermatology Hospital of Zhejiang University School of Medicine  Hangzhou 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