{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:55:39Z","timestamp":1791842139844,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Selective photothermolysis (SPT) using a 1726\u2009nm laser has emerged as a safe and effective treatment option for acne vulgaris by targeting sebaceous glands (SG). Power output plays a crucial role in determining treatment selectivity and efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This work highlights the advantages of a higher\u2010power laser source and outlines the limitations of lower\u2010power laser sources and the subsequent impact on treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Light transport and bioheat transfer simulations were performed to demonstrate photothermal impact on the SG and the surrounding dermis when irradiated by a high\u2010 or lower\u2010power laser source.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The simulations showed that a single higher\u2010power\u2010shorter\u2010pulse (HPSP) selectively increases SG temperature well beyond bulk temperatures, which is desirable for SPT. Selectivity decreases linearly with power for the single lower\u2010power\u2010longer\u2010pulses (LPLP) exposure. A multiple\u2010LPLP approach elevates bulk temperatures significantly more than a single\u2010pulse strategy, compromising selectivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The goal of SPT is to damage SG safely and effectively by creating an intense temperature rise localized to the SG while moderately increasing the dermis temperature. This goal is mostly achieved with higher\u2010power lasers that deliver a single HPSP. Lower\u2010power lasers, longer pulse widths, and multi\u2010pulse strategies result in higher bulk temperatures and lower SG selectivity, making such treatment challenging to execute while adding a higher risk of discomfort and downtime.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16020","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:55:49Z","timestamp":1696308949000},"page":"457-463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Selective photothermolysis in acne treatment: The impact of laser power"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1213-1302","authenticated-orcid":false,"given":"Matteo Giuseppe","family":"Scopelliti","sequence":"first","affiliation":[{"name":"Cutera, Inc.  Brisbane California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9398-8502","authenticated-orcid":false,"given":"Amer","family":"Hamidi\u2010Sakr","sequence":"additional","affiliation":[{"name":"Cutera, Inc.  Brisbane California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f6nke","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Cutera, Inc.  Brisbane California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Karavitis","sequence":"additional","affiliation":[{"name":"Cutera, Inc.  Brisbane California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amogh","family":"Kothare","sequence":"additional","affiliation":[{"name":"Cutera, Inc.  Brisbane California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15043"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000246114"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.09.056"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1370\/afm.2445"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.11.084"},{"issue":"3","key":"e_1_2_10_7_1","first-page":"28","article-title":"Therapeutic and aesthetic uses of photodynamic therapy part two of a five\u2010part series: lasers and light treatments for acne vulgaris promising therapies","volume":"1","author":"Gold MH","year":"2008","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764170600915985"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.02.018"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15602"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21085"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21132"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1364\/boe.7.002311"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1117\/12.2225434"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6836297"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-013-1445-8"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-022-03645-6"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T07:16:50Z","timestamp":1706253410000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,2]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/jocd.16020"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16020","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,2]]},"assertion":[{"value":"2023-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}