{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:31:12Z","timestamp":1787725872778,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral collagen peptides supplementation was reported to improve skin integrity and counteract skin aging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>A randomized, double\u2010blinded, placebo\u2010controlled study was conducted to clinically evaluate the impact of low\u2010molecular\u2010weight collagen peptides on the human skin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>\n                      Healthy adult participants (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009100) were randomly assigned to receive a test product containing low\u2010molecular\u2010weight collagen peptides or a placebo. Parameters of skin wrinkles, elasticity, hydration, and whitening (melanin and erythema indexes) were measured at baseline and after 4, 8, and 12\u2009weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with the placebo group, the average skin roughness, maximum of all peak\u2010to\u2010valley values, maximum peak height of the wrinkle, and average maximum height of the wrinkle were significantly improved in the test group. Parameters of skin elasticity, including overall elasticity, net elasticity, and biological elasticity, were also significantly improved in the test group at Week 12 as compared with the placebo group. Moreover, skin hydration and whitening parameters changed more significantly in the test group than in the placebo group. None of the participants experienced adverse events related to the test product.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Taken together, these findings suggest that low\u2010molecular\u2010weight collagen peptides supplementation can safely ehance human skin wrinkling, hydration, elasticity, and whitening properties.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16026","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:49:11Z","timestamp":1697071751000},"page":"554-562","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Low\u2010molecular\u2010weight collagen peptides supplement promotes\u00a0a healthy skin: A randomized, double\u2010blinded, placebo\u2010controlled study"],"prefix":"10.1111","volume":"23","author":[{"given":"Seol Hwa","family":"Seong","sequence":"first","affiliation":[{"name":"Department of Dermatology Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine  Seoul Korea"},{"name":"Scar Laser and Plastic Surgery Center Yonsei Cancer Hospital, Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6831-7379","authenticated-orcid":false,"given":"Young In","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine  Seoul Korea"},{"name":"Scar Laser and Plastic Surgery Center Yonsei Cancer Hospital, Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7379-1195","authenticated-orcid":false,"given":"Joohee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sooyeon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Ah","family":"Kim","sequence":"additional","affiliation":[{"name":"Global Medical Research Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jangmi","family":"Suk","sequence":"additional","affiliation":[{"name":"Global Medical Research Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inhee","family":"Jung","sequence":"additional","affiliation":[{"name":"Global Medical Research Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaemin","family":"Baeg","sequence":"additional","affiliation":[{"name":"Global Medical Research Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhak","family":"Kim","sequence":"additional","affiliation":[{"name":"R&amp;D Division Daehan Chemtech Co., Ltd.  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Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine  Seoul Korea"},{"name":"Scar Laser and Plastic Surgery Center Yonsei Cancer Hospital, Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13555"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01544.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2013.06.004"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13435"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf062834s"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.02.091"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.00827.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b15-00624"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf9031487"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/09168451.2019.1580559"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000351376"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10070826"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2022.K.0097"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S123575"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026028303196"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2013.3060"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3746\/pnf.2012.17.4.245"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12174"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.2.871"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.6b05679"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf802785h"},{"key":"e_1_2_11_23_1","first-page":"9","article-title":"An antiaging skin care system containing alpha hydroxy acids and vitamins improves the biomechanical parameters of facial skin","volume":"8","author":"Tran D","year":"2015","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12051"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics4040042"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2021.K.0124"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T02:16:53Z","timestamp":1706235413000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,11]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/jocd.16026"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16026","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,11]]},"assertion":[{"value":"2023-05-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}