{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T21:02:07Z","timestamp":1787950927227,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Acne vulgaris<\/jats:italic>\n                      (acne) is characterized by both inflammatory and non\u2010inflammatory lesions. Benzoyl peroxide (BPO) 5% is approved to treat acne but may cause skin irritation and\/or contact allergy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To compare the benefit in acne of a multitargeted dermocosmetic cream containing salicylic acid, lipohydroxy acid, niacinamide, 2\u2010oleamido\u20101,3\u2010octadecanediol, piroctone olamine, zinc,\n                      <jats:italic>Aqua posae filiformis<\/jats:italic>\n                      , and thermal spring water (DC\u2010Eff) to BPO 5% gel.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>150 Caucasian subjects (50% female) aged between 18 and 40\u2009years, with mild to moderate acne according to the GEA (Global Evaluation of Acne) grading system were randomized into two parallel groups (DC\u2010Eff or BPO to be applied twice daily for 56\u2009days). IGA (investigator global assessment), GEA, lesion count, clinical signs and symptoms, and subject assessment were evaluated at baseline, and after 28 and 56\u2009days (D28 and D56) of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The responder analyses of the IGA and GEA scores showed that 62.2% and 47.3%, respectively, in the DC\u2010Eff, compared with 50.0% and 36.5%, respectively, in the BPO, had improved by at least one point at D56. Inflammatory, non\u2010inflammatory, and total lesion counts significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) decreased with both products from baseline, with no between\u2010group difference. Subjects considered that their skin was smoother and that DC\u2010Eff was easy to apply. DC\u2010Eff was better tolerated than BPO.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DC\u2010Eff applied twice daily is as beneficial as BPO in improving mild\u2010to\u2010moderate acne. DC\u2010Eff was better tolerated than BPO and highly appreciated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16052","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:02:42Z","timestamp":1699488162000},"page":"891-897","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Efficacy of a multitargeted, salicylic acid\u2010based dermocosmetic cream compared to benzoyl peroxide 5% in\n                    <i>Acne vulgaris<\/i>\n                    : Results from a randomized study"],"prefix":"10.1111","volume":"23","author":[{"given":"Susi Elaine","family":"Dal\u00a0Belo","sequence":"first","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Aulnay\u2010Sous\u2010Bois France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Kanoun\u2010Copy","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation 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