{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:13:08Z","timestamp":1787015588246,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acne vulgaris is one of the most common skin conditions in dermatology clinics. Accumulating evidence has implicated oral low\u2010dosage isotretinoin was an effective treatment for acne with fewer side effects. Currently, the data on low\u2010dosage isotretinoin use in Chinese is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the efficiency and safety of low\u2010dosage isotretinoin therapy for Chinese acne patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three hundred and eighty\u2010eight patients treated with low\u2010dosage isotretinoin (0.2\u20130.4\u2009mg\/kg\/d) and who completed the course (120\u2009mg\/kg) were enrolled. Medical information on the severity, duration, adverse effects, and outcome of acne was reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The majority (90.2%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009350) of patients achieved complete remission, and on average, patients received 13.5\u2009months of treatment. The time between isotretinoin start and the clear date between the mild and moderate groups was not significantly different (74\u2009\u00b1\u200924 vs. 84\u2009\u00b1\u200924\u2009days). However, it took longer to resolve for the severe acne group (112\u2009\u00b1\u200925\u2009days). Follow\u2010up 1\u2009year after completion of the isotretinoin course, 37\/350 (10.6%) patients relapsed, but there was no difference in the severity of acne. There were 133 (34.3%), 40 (10.3%), and 14 (2.6%) patients who developed hypercholesterolemia, hypertriglyceridemia, and high LDL, respectively. Thirty\u2010two (8.2%) and 28 patients (7.2%) had elevated serum levels of alanine and aspartate aminotransferases. No values above grade 2 were detected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study reaffirms the efficacy and safety of low\u2010dosage oral isotretinoin in Chinese patients with acne vulgaris. Lab investigation could be performed after 2\u2009months of therapy in healthy patients with normal baseline liver function and lipid panel tests.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16073","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T15:58:22Z","timestamp":1699372702000},"page":"926-930","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The efficiency and safety of low\u2010dosage isotretinoin therapy for Chinese acne vulgaris patients"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6802-3570","authenticated-orcid":false,"given":"Yiting","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Minhang Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zile","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouwei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.3091"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000246134"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-020-00508-0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1325"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/2277-9175.129693"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14438"},{"issue":"4","key":"e_1_2_10_8_1","first-page":"441","article-title":"A dietary supplement to reduce side effects of oral isotretinoin therapy in acne patients","volume":"149","author":"Fabbrocini G","year":"2014","journal-title":"G Ital Dermatol Venereol"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13675"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.2044"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2012.672708"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.11.1061"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2165\/11539570-000000000-00000"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.10.030"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0365-05962010000300006"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.03.019"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.06.025"},{"issue":"6","key":"e_1_2_10_18_1","first-page":"557","article-title":"Isotretinoin monitoring trends: a National Survey of dermatologists","volume":"16","author":"Hobson JG","year":"2017","journal-title":"J Drugs Dermatol"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16073","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.16073","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T06:16:25Z","timestamp":1771395385000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,7]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/jocd.16073"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16073","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,7]]},"assertion":[{"value":"2023-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}