{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T14:29:55Z","timestamp":1782570595192,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prurigo nodularis (PN) is an intensively pruritic skin disease that negatively influences quality of life. Cryosim\u20101 (Intrinsic IB Spot) is a synthetic, selective transient receptor potential melastatin 8 agonist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the efficacy and safety of cryosim\u20101 in PN patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>A randomized, double\u2010blinded, placebo\u2010controlled clinical trial including 30 patients was conducted. The numerical rating scale (NRS) of pruritus was evaluated before and 2\u2009h after cryosim\u20101 application at every visit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At week 8, the mean pruritus NRS before serum application (4.7\u2009\u00b1\u20090.4 treatment, 6.1\u2009\u00b1\u20090.5 placebo;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045) and 2\u2009h after serum application (2.8\u2009\u00b1\u20090.4 treatment, 4.3\u2009\u00b1\u20090.5 placebo;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031) were significantly lower in the treatment group, and the mean NRS for sleep disorder was significantly lower in the treatment group (2.2\u2009\u00b1\u20090.5 treatment, 4.2\u2009\u00b1\u20090.8 placebo;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031). The mean satisfaction scales for pruritus improvement were significantly higher in the treatment group (7.2\u2009\u00b1\u20090.6) than in the placebo group (4.0\u2009\u00b1\u20090.9;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005). There was no difference in TEWL between the two groups, and no adverse reactions were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cryosim\u20101 is a safe and effective topical treatment for PN patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16079","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:59:25Z","timestamp":1704243565000},"page":"931-937","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A randomized, double\u2010blinded, vehicle\u2010controlled clinical trial of topical cryosim\u20101, a synthetic\n                    <scp>TRPM8<\/scp>\n                    agonist, in prurigo nodularis"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7514-7873","authenticated-orcid":false,"given":"Myoung Eun","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Dermatology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Hyeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Bio\u2010Medical Institute of Technology (BMIT), University of Ulsan, College of Medicine  Ulsan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Jin","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong Hyun","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Eun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of 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