{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:08:50Z","timestamp":1788566930015,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Skin aging is characterized by wrinkles, rough skin texture, pigmentation, facial erythema, and telangiectasia through structural and functional changes in the epidermis and dermis. Recently, injectable poly(D, L\u2010lactic acid), a biodegradable polymer, has been used widely for skin rejuvenation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aims to assess the efficacy and safety of injectable dermal poly D, L\u2010lactic acid) for skin rejuvenation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>A total of 16 patients who desired skin rejuvenation were included. All participants received two or three procedure sessions with a 4\u2009weeks interval between sessions. Clinical and three\u2010dimensional images at baseline, before each procedural session, and follow\u2010up visits were obtained. Therapeutic effects were assessed by evaluating signs of aging skin and overall improvement by dermatologists and patients. Histologic examinations with special stains were performed on the posterior auricular areas of consenting patients at baseline and follow\u2010up visits after injecting poly D L\u2010lactic acid into the postauricular area as in the face.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, statistically significant differences were observed in all signs of aging skin, such as fine wrinkles, skin texture, irregular pigmentation, telangiectasia, and facial erythema before and after treatments. Half (50%) of patients responded that there was more than 50% overall improvement. There were no severe adverse events. Histologic examination demonstrated increases in collagen and elastic fibers in the dermis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Results of this preliminary study suggest that injectable dermal poly D, L\u2010lactic acid can significantly affect skin rejuvenation without causing any serious adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16085","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T02:40:30Z","timestamp":1700102430000},"page":"794-802","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Skin rejuvenation effect of the combined\n                    <scp>PDLLA<\/scp>\n                    and non cross\u2010linked hyaluronic acid: A preliminary study"],"prefix":"10.1111","volume":"23","author":[{"given":"Suk Bae","family":"Seo","sequence":"first","affiliation":[{"name":"SeoAh Song Dermatologic Clinic  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunwoo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Korea University Ansan Hospital, Korea University  Ansan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Young","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Korea University Ansan Hospital, Korea University  Ansan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwa Jung","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Korea University Ansan Hospital, Korea University  Ansan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00889.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2009.5"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.476"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.4236\/jcdsa.2012.21006"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S266015"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1578-2190(10)70660-0"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12852"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-947720"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22580"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12950"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12061204"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12091320"},{"key":"e_1_2_11_14_1","article-title":"Injectable poly\u2010D, L\u2010lactic acid in facial rejuvenation: three case reports","volume":"4","author":"Lin IJY","year":"2020","journal-title":"Cosmetol J"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15047"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000480686.68275.60"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2017.1358459"},{"issue":"6","key":"e_1_2_11_18_1","first-page":"E65","article-title":"Vascular complications after facial filler injection: a literature review and meta\u2010analysis","volume":"12","author":"Sito G","year":"2019","journal-title":"J Clin Aesthet 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