{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:53:24Z","timestamp":1792508004580,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Topical minoxidil is the recommended first\u2010line pharmacologic treatment for male and female pattern hair loss. However, low\u2010dose oral minoxidil has been used off\u2010label with good clinical efficacy and safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare the effectiveness and safety of topical minoxidil as a first\u2010choice treatment of androgenetic alopecia versus 1\u2009mg daily oral minoxidil.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Sixty\u2010five AGA patients were randomly allocated to receive either 5% topical solution or 1\u2009mg\/day oral minoxidil for 6\u2009months. Treatment efficacy was evaluated by measuring hair diameter, photographic assessment, and patient self\u2010assessment questionnaires. The safety of treatment was checked through history taking and physical examination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both topical and oral minoxidil groups showed significant improvement in hair diameter after 6\u2009months of treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). However, there was no significant difference between the two groups. The photographic assessment demonstrated a significant improvement in hair density in the topical minoxidil group in all marked points located at 12\u2009cm (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025), 16\u2009cm (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034), and 24\u2009cm (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014) distance from the glabella but not in the oral minoxidil group. Nevertheless, the difference between the two groups was not significant. In each group, over 60% of patients expressed satisfaction with their treatments, and no significant difference was detected between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although topical minoxidil has a better overall therapeutic effect than 1\u2009mg oral minoxidil, the difference between the two groups was not significant. Therefore, 1\u2009mg oral minoxidil may be as effective and safe as standard topical minoxidil in female and male pattern hair loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16086","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T02:29:25Z","timestamp":1701311365000},"page":"949-957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Clinical efficacy and safety of low\u2010dose oral minoxidil versus topical solution in the improvement of androgenetic alopecia: A randomized controlled trial"],"prefix":"10.1111","volume":"23","author":[{"given":"Ali","family":"Asilian","sequence":"first","affiliation":[{"name":"Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, School of Medicine Isfahan University of Medical Sciences  Isfahan 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