{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:35:39Z","timestamp":1788428139587,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several treatment modalities are used for the treatment of periorbital rejuvenation with variable results. Recent studies showed that fractional radiofrequency may be an effective treatment modality for periorbital aging. This study aims to determine the efficacy and safety of negative pressure fractional microneedle radiofrequency (NPFMR) as a treatment for periorbital aging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010five patients with periorbital aging were involved in this study. They were treated two times with an interval of 1\u2009month. The patients were evaluated before treatment and 1, 3, and 6\u2009months after the final treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The research findings suggest that periorbital wrinkles of the patients were significantly improved by VISIA system (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Physiological indicators detected by MPA10 system showed that compared with before treatment, the hydration increased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and trans epidermal water loss (TEWL) decreased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) at 3 and 6\u2009months after treatment. The glossiness increased at 1\u2009month after treatment compared to pre\u2010treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and returned to the baseline level at 3 and 6\u2009months after treatment. There was no significant change in melanin content (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Periorbital dermal thickness of the patients significantly increased at 1, 3, and 6\u2009months after treatment according to skin ultrasound (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). A periorbital skin biopsy revealed that the collagen fibers in the dermis were significantly thicker and more orderly after treatment, and the expression of type I collagen fibers and elastic fibers was increased compared with that before treatment. One patient developed post\u2010inflammatory hyperpigmentation (PIH) at 1\u2009month after the first treatment, which improved after active treatment. No other adverse reactions were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NPMFR could be an effective and safe treatment modality for the treatment of periorbital aging.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16091","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T07:21:11Z","timestamp":1701156071000},"page":"1269-1276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Treatment of periorbital aging with negative pressure fractional microneedle radiofrequency: A self\u2010controlled clinical trial"],"prefix":"10.1111","volume":"23","author":[{"given":"Yulian","family":"Gao","sequence":"first","affiliation":[{"name":"Medical Cosmetic Center Chengdu Second People's Hospital  Chengdu 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