{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:01:29Z","timestamp":1787497289113,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100017218","name":"Giresun \u00dcniversitesi","doi-asserted-by":"publisher","award":["SA\u011e\u2010BAP\u2010A\u2010250221\u201033"],"award-info":[{"award-number":["SA\u011e\u2010BAP\u2010A\u2010250221\u201033"]}],"id":[{"id":"10.13039\/100017218","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The link between rosacea and various systemic conditions has been growing in prominence, even though the relationship between rosacea and cardiovascular disease remains a subject of debate in current research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Detecting the connection between rosacea and subclinical atherosclerosis using laboratory and ultrasonographic parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty rosacea patients and 49 control were included in the study. Demographic, clinical, and laboratory data, including serum high sensitivity C\u2010reactive protein (hs\u2010CRP), fetuin\u2010A (FA), and matrix gla protein levels were assessed. Carotid intima\u2010media thickness (CIMT) was measured by carotid ultrasonography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Serum hs\u2010CRP levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009) and mean CIMT (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) were significantly higher, while serum FA levels were significantly lower (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) in the rosacea patients compared with control. The number of patients with mean CIMT&gt;75th percentile according to age and sex were significantly higher in the rosacea group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Rosacea patients with ocular involvement exhibited significantly higher hs\u2010CRP values in comparison to those without ocular involvement (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008). No significant correlation was detected between disease duration, severity, subtype and the study parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study results suggest that rosacea poses an independent risk for subclinical atherosclerosis regardless of its severity, duration, or subtype. Therefore, individuals diagnosed with rosacea should receive careful evaluation and monitoring to detect possible cardiovascular complications promptly. Furthermore, our study hints at a potential elevated risk of subclinical inflammation in rosacea patients with ocular involvement, warranting additional attention and further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16094","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T10:48:22Z","timestamp":1700736502000},"page":"1075-1084","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of atherosclerotic risk in rosacea patients through serum\n                    <scp>fetuin\u2010A<\/scp>\n                    and carotid intima media thickness"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7886-1060","authenticated-orcid":false,"given":"Sevgi","family":"Kulakl\u0131","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Giresun University Faculty of Medicine  Giresun 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