{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:26:27Z","timestamp":1787502387344,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ultrasound energy has been used for dermal rejuvenation to treat fine lines, wrinkles and to lift lax skin. High intensity ultrasound waves induce thermal injury in the dermis, stimulating neocollagenesis and neoelastinogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the efficacy, utility, and safety of a novel ultrasound device that uses high\u2010intensity, high\u2010frequency, non\u2010focused ultrasound parallel beams to lift lax facial skin in the eyebrow, submental, and neck areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Fifteen subjects aged 40\u201369\u2009years were enrolled in a prospective clinical trial. Two treatment sessions were performed with the high\u2010intensity non\u2010focused ultrasound parallel beam device followed by 3\u2010 and 6\u2010month follow\u2010up visits. Treatment results were assessed by study investigators, evaluating baseline and posttreatment photographs by applying physician global aesthetic improvement scale. Pain was evaluated immediately after each treatment using 0\u201310 visual analog scale. Any adverse event that occurred during the study period was documented and examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifteen subjects with a mean age of 55\u2009\u00b1\u20092\u2009years completed the study. Photographs that were taken at baseline and follow\u2010up visits were compared and examined. An improvement pattern was detected in all treated areas in both follow\u2010up visits and persisted stably throughout the study. The mean pain score was 5.6 according to the visual analog scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The novel ultrasound device that uses high\u2010intensity, high\u2010frequency, non\u2010focused ultrasound parallel beam was shown to improve safely and efficiently facial lax skin resulting in eyebrow, submental, and neck skin lift while experiencing tolerable pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16098","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T02:54:36Z","timestamp":1701312876000},"page":"117-123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Efficacy and safety of high\u2010intensity, high\u2010frequency, non\u2010focused ultrasound parallel beams for facial skin laxity"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5183-5433","authenticated-orcid":false,"given":"Michael H.","family":"Gold","sequence":"first","affiliation":[{"name":"The Tennessee Clinical Research Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Biron","sequence":"additional","affiliation":[{"name":"The Tennessee Clinical Research Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000475758.63709.23"},{"key":"e_1_2_9_3_1","unstructured":"American Society of Plastic Surgeons.Plastic Surgery Statistics Report. 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