{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:30:08Z","timestamp":1789684208227,"version":"4.0.1"},"reference-count":75,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tranexamic acid (TA) is a new and promising drug for the treatment of melasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This network meta\u2010analysis aims to compare the efficacy and safety of various ways of administration of TA on melasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected researches from PubMed, EMBASE, Cochrane Library and Web of Science. Melasma area severity index (MASI) is used to evaluate the severity of melasma. After treatment with different TA administration methods, a difference in MASI is named \u0394MASI. We evaluate the curative effect by comparing the \u0394MASI of different TA administration methods at a certain time point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the Weeks 4, 8, and 12 and the last follow\u2010up, the \u0394MASI of oral TA combined with routine topical agents (oTA\u2009+\u2009RTA) was higher than that of intradermal TA (iTA), topical TA (tTA) as well as microneedling TA (MNsTA), with statistical significance. At the 8th week, the \u0394MASI of oTA was higher than that of iTA, with statistical significance. Compared with placebo, oTA showed statistically significant differences at Week 4, while tTA, iTA, and MNsTA showed statistically significant differences starting from Week 8.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among various ways of administration of TA, oTA\u2009+\u2009RTA has the best effect on melasma. In the short term, the curative effect of oTA is better than that of iTA, and the onset time of oTA is faster than that of tTA, iTA and MNsTA. In the long run, the curative effect of TA alone has nothing to do with the mode of administration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16104","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T04:28:42Z","timestamp":1702009722000},"page":"1150-1164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Comparative efficacy and safety of tranexamic acid for melasma by different administration methods: A systematic review and network meta\u2010analysis"],"prefix":"10.1111","volume":"23","author":[{"given":"Rongzhou","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Laser Cosmetology The Sixth People's Hospital of Dongguan  Dongguan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Laser Cosmetology The Sixth People's Hospital of Dongguan  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