{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:22:47Z","timestamp":1780496567740,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is no evidence\u2010based guidance on the use of fractional CO<jats:sub>2<\/jats:sub> laser in the excision of scars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To explore the effectiveness and safety of fractional CO<jats:sub>2<\/jats:sub> laser in the treatment of keloids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this meta\u2010analysis, we searched the PubMed, Embase, and Cochrane databases from inception to April 2023. We only included studies reporting fractional CO<jats:sub>2<\/jats:sub> laser treatment of keloids. We excluded duplicate published studies, incomplete studies, those with incomplete data, animal experiments, literature reviews, and systematic studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pooled results showed that the Vancouver Scar Scale (VSS) parameters of height weighted mean difference (WMD)\u2009=\u2009\u22121.10, 95% confidence interval (CI): \u22121.46 to \u22120.74), pigmentation (WMD\u2009=\u2009\u22120.61, 95% CI: \u22121.00 to \u22120.21), and pliability (WMD\u2009=\u2009\u22120.90, 95% CI: \u22121.17 to \u22120.63) were significantly improved after fractional CO<jats:sub>2<\/jats:sub> laser treatment of keloids. However, vascularity did not significantly change. Additionally, the total VSS was significantly improved after treatment (WMD\u2009=\u2009\u22124.01, 95% CI: \u22126.22 to \u22121.79). The Patient Scars Assessment Scale was significantly improved after treatment (WMD\u2009=\u2009\u221215.31, 95% CI: \u221218.31 to \u221212.31). Regarding safety, the incidences of hyperpigmentation, hypopigmentation, pain, telangiectasia, and atrophy were 5%, 0%, 11%, 2% (95% CI: 0%\u20136%), and 0% (95% CI: 0%\u20134%), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fractional CO<jats:sub>2<\/jats:sub> laser is effective in the treatment of keloids and can effectively improve the height, pigmentation, and pliability of scars, and patients are satisfied with this treatment. Further studies should explore the role of combination therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16106","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T11:49:16Z","timestamp":1705924156000},"page":"1178-1186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Application of fractional carbon dioxide laser monotherapy in keloids: A meta\u2010analysis"],"prefix":"10.1111","volume":"23","author":[{"given":"Jinhui","family":"Wang","sequence":"first","affiliation":[{"name":"Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated Hospital of Integrated Traditional Chinese and Western Medicine of Shanghai University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yu","sequence":"additional","affiliation":[{"name":"Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated Hospital of Integrated Traditional Chinese and Western Medicine of Shanghai University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiujun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of First Clinical Medical College Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maocan","family":"Tao","sequence":"additional","affiliation":[{"name":"The First Affliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Cao","sequence":"additional","affiliation":[{"name":"The First Affliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Yang","sequence":"additional","affiliation":[{"name":"The First Affliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41038-018-0129-9"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14121"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-014-1507-1"},{"key":"e_1_2_12_5_1","first-page":"360","article-title":"The keloid disorder: heterogeneity, histopathology, mechanisms and models, front cell","volume":"8","author":"Limandjaja GC","year":"2020","journal-title":"Dev 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of fractional carbon dioxide laser (FCO(2)) with Intralesional 5\u2010fluorouracil (5\u2010FU) in the treatment of keloids","volume":"14","author":"Alhamzawi NK","year":"2021","journal-title":"J Cutan Aesthet Surg"},{"key":"e_1_2_12_19_1","article-title":"Fractional carbon dioxide (co[2]) laser alone versus fractional co(2) laser combined with triamcinolone acetonide or trichloroacetic acid in keloid treatment: a comparative clinical and radiological study","volume":"12","author":"El\u2010Hamid El\u2010Azhary EA","year":"2022","journal-title":"Dermatol Pract 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