{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:19:33Z","timestamp":1784819973414,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Topical retinoids cause retinoid\u2010induced skin discomfort (RISD) mainly during the first weeks of use leading to noncompliance and premature treatment discontinuation. A dermocosmetic (DC) may help to reduce treatment\u2010related signs and symptoms and improve adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the benefit of a DC regimen compared to a routine skin care regimen (RC) by reducing RISD signs and symptoms induced by a retinoid\/benzoyl peroxide fixed\u2010drug combination in subjects with acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Double\u2010blind, randomized, comparative study in subjects \u226516\u2009years with mild to moderate acne candidates to a topical adapalene\/BPO fixed drug combination (A\/BPO). Evaluations took place at Day 0, 7, 14, 28, and 84 and included erythema, desquamation, burning, itching and stinging and RISD (SD, a composite score of local treatment\u2010related signs and symptoms and acne severity. Subjects used daily the DC or RC together with the fixed combination for 84\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010eight subjects were included, the mean age was 21\u2009years; 84% were females. At Day 0 the SD score was 0.8 in both groups. A statistically significant difference in terms of skin sensitivity with DC compared to RC (1.6 points, vs. 2.4 points <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) was observed at Day 14. Clinical sign and symptom scores were more reduced with DC than with RC at all time points. Acne severity improved in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DC significantly reduces A\/BPO\u2010related RISD compared to RC, especially during the first 14\u2009days of treatment, without interfering with the clinical efficacy of the treatment, thus helping to maintain treatment adherence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16120","type":"journal-article","created":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T08:06:50Z","timestamp":1702714010000},"page":"1313-1319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A dermocosmetic regimen is able to mitigate skin sensitivity induced by a retinoid\u2010based fixed combination treatment for acne: Results of a randomized clinical trial"],"prefix":"10.1111","volume":"23","author":[{"given":"Amir","family":"Khammari","sequence":"first","affiliation":[{"name":"Department of Dermatology Nantes University, CHU Nantes, CIC 1413, INSERM, CNRS, Immunology and New Concepts in ImmunoTherapy, INCIT  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2816-4261","authenticated-orcid":false,"given":"Delphine","family":"Kerob","sequence":"additional","affiliation":[{"name":"La Roche\u2010Posay Laboratoire Dermatologique  Levallois\u2010Perret France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann\u2019 Laure","family":"Demessant","sequence":"additional","affiliation":[{"name":"La Roche\u2010Posay Laboratoire Dermatologique  Levallois\u2010Perret France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot","family":"Nior\u00e9","sequence":"additional","affiliation":[{"name":"La Roche\u2010Posay Laboratoire Dermatologique  Levallois\u2010Perret 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