{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:57:07Z","timestamp":1790812627134,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Treatment of infraorbital dark circles and under\u2010eye puffiness is challenging due to its multifactorial nature and lack of broadly applicable, effective treatments. A daily skincare treatment option that is multimodal, effective, and tolerable across a broad patient population is an unmet need.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      A multicorrective topical eye cream (MTEC) formulated with Tetrahexyldecyl (THD) ascorbate (vitamin C), prebiotic\n                      <jats:italic>Inula Helenium<\/jats:italic>\n                      , bioavailable peptides, botanical extracts, chrysin, and caffeine is hypothesized to improve the appearance of infraorbital dark circles and under\u2010eye puffiness by targeting microvasculature congestion and permeability, melanin accumulation and hemoglobin degradation\u2010related pigmentation, and skin health.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      An IRB approved, open\u2010label, 12\u2010week clinical study set out to evaluate the efficacy and tolerability of the MTEC across a broad patient population including varying ethnicities and Fitzpatrick Skin Types (FST). Female subjects (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940) ages 35\u201360\u2009years old, with moderate\u2010to\u2010severe under\u2010eye dark circles, moderate under\u2010eye puffiness, and mild\u2010to\u2010moderate fine lines were enrolled into the study. Objective (Chromameter, VISIA\u00ae imaging, and Laser Doppler) and subjective assessments (clinical grading and self\u2010assessment questionnaire) were conducted at baseline and post\u2010baseline timepoints.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010seven subjects completed the study, and the MTEC efficaciously demonstrated short\u2010term and long\u2010term improvements in objective and subjective assessments across a broad patient population. Specifically, the MTEC demonstrated significant improvement of infraorbital dark circles, mainly by the reduction in microvasculature congestion and permeability, melanin, and hemoglobin degradation\u2010related pigmentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Topical application of the MTEC may offer an effective and tolerable treatment option for infraorbital dark circles and puffiness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16122","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T06:40:30Z","timestamp":1702968030000},"page":"486-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effectiveness and tolerance of\n                    <scp>multicorrective<\/scp>\n                    topical treatment for infraorbital dark circles and puffiness"],"prefix":"10.1111","volume":"23","author":[{"given":"Ali","family":"Rajabi\u2010Estarabadi","sequence":"first","affiliation":[{"name":"Department of Dermatology, Broward health Fort Lauderdale Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey L.","family":"Hartman","sequence":"additional","affiliation":[{"name":"Skin Wellness Dermatology Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Iglesia","sequence":"additional","affiliation":[{"name":"Revision Skincare\u00ae Irving Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Kononov","sequence":"additional","affiliation":[{"name":"Revision Skincare\u00ae Irving Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6964-0776","authenticated-orcid":false,"given":"Alisar S.","family":"Zahr","sequence":"additional","affiliation":[{"name":"Revision Skincare\u00ae Irving Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2000.98159.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.185707"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02065.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S217956"},{"issue":"3","key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4103\/0974-2077.101373","article-title":"Idiopathic cutaneous hyperchromia at the orbital region or periorbital hyperpigmentation","volume":"5","author":"Sarkar R","year":"2012","journal-title":"J Cutan Aesthet Surg"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.184046"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2494.2004.00242_2.x"},{"key":"e_1_2_8_9_1","volume-title":"Physiology, Bilirubin","author":"Kalakonda A","year":"2022"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12074"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2009.00356.x"},{"issue":"2","key":"e_1_2_8_12_1","first-page":"18","article-title":"Effectiveness and safety of topical under\u2010eye serum in patients with periorbital hyperpigmentation: An open\u2010label single arm prospective study","volume":"15","author":"Chandrashekar BS","year":"2022","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002484"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1990.tb17997.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14080702"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2012.08.009"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2006.07.001"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22032"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1559325817711782"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.628314"},{"key":"e_1_2_8_21_1","unstructured":"HavasF KrispinS CohenM ShevachM Borenstein\u2010AuerbachN.Restore and renew: inula helenium powers up Skin's anti\u2010pollution defenses. 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