{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:56:22Z","timestamp":1787507782075,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972954"],"award-info":[{"award-number":["81972954"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Baricitinib is a small\u2010molecular drug that selectively inhibits the Janus Kinase (JAK) 1 and 2. However, it showed various efficiency and safety in treating moderate\u2010to\u2010severe alopecia areata (AA). This study was to describe the real\u2010world effectiveness of baricitinib in treating moderate\u2010to\u2010severe refractory AA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who were affected by moderate\u2010to\u2010severe AA and reported no shrinkage in the alopecia area after 6\u2009months of conventional treatment were enrolled in the retrospective study. The patients were treated with baricitinib orally for at least 24\u2009weeks. The severity of alopecia was evaluated at the end of 4, 12, and 24\u2009weeks of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 32 patients included 23 females and nine males, with a median duration of AA of 14.5\u2009months. Among them, 28 patients received baricitinib 2\u2009mg per day for 24\u2009weeks while the other four patients increased the daily dose from 2 to 4\u2009mg after the first 12\u2009weeks due to the unobvious hair restoration. SALT value showed a significant decrease from baseline at week 12 and 24 (64.45 [44.68\u2013100.00] vs. 26.80 [13.40\u201362.32],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001 and 64.45 [44.68\u2013100] vs. 9.40 [4.85\u201334.95],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). After 24\u2009weeks of treatment, 50% of patients had an improvement of \u22652 points in IGA scores from the baseline, and IGA scores of 68.75% of patients were less than 2.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This 24\u2010week research showed that baricitinib had favorable clinical efficacy and safety in treating moderate\u2010to\u2010severe AA, which is worthy of attention and expectation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16123","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T07:11:28Z","timestamp":1703056288000},"page":"1417-1421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effectiveness and safety of baricitinib in patients with moderate\u2010to\u2010severe refractory alopecia areata in real world: An\u00a0open\u2010label, single\u2010center study"],"prefix":"10.1111","volume":"23","author":[{"given":"Lingbo","family":"Bi","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6700-8654","authenticated-orcid":false,"given":"Chaofan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimei","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First 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