{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T18:24:13Z","timestamp":1779301453280,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20210324105412033"],"award-info":[{"award-number":["JCYJ20210324105412033"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20220531094004010"],"award-info":[{"award-number":["JCYJ20220531094004010"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Observational studies have showed an association between schizophrenia and risk of psoriasis and vice versa. However, whether schizophrenia is causally associated with psoriasis is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<jats:bold>s<\/jats:bold><\/jats:title><jats:p>A two\u2010sample bidirectional Mendelian randomization (MR) analysis was performed with publicly available genome\u2010wide association study data including schizophrenia (<jats:italic>n<\/jats:italic>\u2009=\u200977\u2009096) and psoriasis (<jats:italic>n<\/jats:italic>\u2009=\u2009462\u2009933). The inverse\u2010variance weighted method was performed as the main analysis, with a complementary with the other two analyses: MR\u2010Egger and weighted median method. A series of sensitivity analyses were also conducted to evaluate the robustness of the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MR analyses indicated that genetically predicted schizophrenia was significantly associated with an increased risk of psoriasis [OR: 1.001, 95% confidence interval (CI): 1.000\u20131.002, <jats:italic>p<\/jats:italic>\u2009=\u20090.012]. However, no causal effect of genetically predicted psoriasis on schizophrenia (OR: 0.221, 95% CI: 0.029\u20131.682, <jats:italic>p<\/jats:italic>\u2009=\u20090.145) was detected. No pleiotropy or heterogeneity was detected in sensitivity analysis (all <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study provides genetic evidence for the causal association between schizophrenia and psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16140","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T06:21:21Z","timestamp":1702621281000},"page":"1465-1471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between schizophrenia and psoriasis: A two\u2010sample bidirectional Mendelian randomization study"],"prefix":"10.1111","volume":"23","author":[{"given":"Yanting","family":"Ou","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Peking University Shenzhen Hospital  Shenzhen China"},{"name":"Medical College Shantou University  Shantou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyi","family":"Qi","sequence":"additional","affiliation":[{"name":"Medical College Shantou University  Shantou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Peking University Shenzhen Hospital  Shenzhen China"},{"name":"Medical College Shantou University  Shantou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Peking University Shenzhen Hospital  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Peking University Shenzhen Hospital  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengfan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Peking University Shenzhen Hospital  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangwen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Peking University Shenzhen Hospital  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1400-1218","authenticated-orcid":false,"given":"Yongyan","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Peking University Shenzhen Hospital  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sby058"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2019.3360"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-032813-153657"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina55070361"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.yco.0000228767.71473.9e"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000508868"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32549-6"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30925-9"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.743180"},{"key":"e_1_2_11_11_1","article-title":"More than skin\u2010deep: the many dimensions of the psoriatic disease","volume":"144","author":"Boehncke WH","year":"2014","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14303"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10684.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.150210"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114131"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyg070"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0579-z"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016010098"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14389-8"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.7221"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv080"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21965"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0099-7"},{"issue":"12","key":"e_1_2_11_24_1","first-page":"2681","article-title":"Invited commentary: detecting individual and global horizontal pleiotropy in Mendelian randomization\u2010a job for the humble heterogeneity statistic?","volume":"187","author":"Bowden J","year":"2018","journal-title":"Am J Epidemiol"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.15555.1"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.038035"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2017.11.021"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/jpgm.JPGM_253_18"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddz145"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)01135-6"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08192"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbu049"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2014.01.001"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-007-0075-1"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T03:14:29Z","timestamp":1711595669000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,14]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/jocd.16140"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16140","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,14]]},"assertion":[{"value":"2023-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}