{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:18:53Z","timestamp":1790914733484,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite similarities in progressive miniaturization of hair follicles and transition of terminal hairs to vellus hairs, insufficient trichoscopic comparisons between male androgenetic alopecia (MAGA) and female pattern hair loss (FPHL) hinder our ability to select effective treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Our study aimed to explore gender\u2010specific trichoscopic characteristics of MAGA and FPHL, while formulating hypotheses regarding the progression of these conditions across clinical stages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We classified 126 male MAGA subjects using Hamilton\u2010Norwood Classification and 57 FPHL subjects using adopted Sinclair Scale. Subsequently, we analyzed nine trichoscopic factors divided into three categories: hair\u2010diameter related, hair\u2010number per follicular unit related, and hair density related factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the nine quantitative trichoscopic factors, hair\u2010diameter and hair\u2010number per follicular unit showed strong correlations with clinical stages in both genders. Hair density, a common trichoscopic factor for hair loss evaluation, weakly correlated with clinical stages in FPHL, but not at all in MAGA. In addition, MAGA was characterized by a progressive reduction in hair\u2010diameter, followed by a reduction in hair\u2010number per follicular unit. FPHL, on the contrary, showed the opposite progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Trichoscopic factors vary with disease severity in a gender\u2010specific manner. Our research highlights that MAGA and FPHL involve two distinct streams: hair\u2010diameter decreasing by hair follicle miniaturization (Stream 1), and hair\u2010number per follicular unit decreasing by hair follicle tri\u2010lineage niche dysfunction (Stream 2). MAGA typically starts from Stream 1 to Stream 2, while FPHL starts from Stream 2. These diverse progression pathways underscore the importance of personalized treatment approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16177","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T07:48:49Z","timestamp":1704700129000},"page":"1828-1839","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Divergent progression pathways in male androgenetic alopecia and female pattern hair loss: Trichoscopic perspectives"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5929-6166","authenticated-orcid":false,"given":"Tomoko","family":"Kamishima","sequence":"first","affiliation":[{"name":"Department of Dermatology Tokyo Midtown Skin\/Aesthetic Clinic Noage  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Hirabe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Midtown Skin\/Aesthetic Clinic Noage  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5553-1245","authenticated-orcid":false,"given":"Khin Zay Yar","family":"Myint","sequence":"additional","affiliation":[{"name":"Tokyo Midtown Center for Advanced Medical Science and Technology  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1073-2913","authenticated-orcid":false,"given":"Junichi","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Tokyo Midtown Clinic  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,8]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Endotext","author":"Asfour 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