{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:17:10Z","timestamp":1777933030553,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary cutaneous macular amyloidosis (PCMA) is a chronic pruritic cutaneous disease characterized by heterogeneous extracellular deposition of amyloid protein in the skin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to evaluate the efficacy of topical 6% gabapentin cream for the treatment of patients with PCMA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In this triple\u2010blind clinical trial, a total of 34 patients, who were diagnosed with PCMA, treated using two different strategies of topical gabapentin as the active group and vehicle cream as the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Pruritus score reduction in both groups was statistically significant compared with the baseline value (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). There was a significant pigmentation score reduction in intervention group compared with control group after 1\u2009month of the study (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The differences of pigmentation score changes between the groups were not significant at month 2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.52) and month 3 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.22).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results of this study suggest that topical gabapentin cream may be effective as a topical agent in the treatment of pruritus associated with PCMA without any significant adverse effects. It is recommended to perform similar studies with a larger sample size and longer duration in both sexes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16180","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:45:06Z","timestamp":1706661906000},"page":"1677-1684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of topical gabapentin in women with primary macular amyloidosis: A side\u2010by\u2010side triple\u2010blinded randomized clinical trial"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1081-9477","authenticated-orcid":false,"given":"Bahareh","family":"Abtahi\u2010Naeini","sequence":"first","affiliation":[{"name":"Pediatric Dermatology Division of Department of Pediatrics, Imam Hossein Children's Hospital Isfahan University of Medical Sciences  Isfahan Iran"},{"name":"Skin Diseases and Leishmaniasis Research 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