{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:23:24Z","timestamp":1790810604315,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Androgenetic alopecia (AGA), also referred to as male or female pattern hair loss, is the commonest cause of chronic hair loss and affects up to 80% of men by the age of 70. Despite a high prevalence, there are few approved therapies, which show minimal efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This systematic review aims to evaluate the efficacy of platelet\u2010rich plasma (PrP) in the treatment of AGA in male patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      MEDLINE, EMBASE, Cochrane (CENTRAL), CINAHL,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                      , Google Scholar and the Science Citation Index database were searched to identify eligible studies. All randomized controlled trials (RCTs) and prospective cohort studies related to PrP use in AGA were included. Primary outcomes included changes in hair density and hair count. Methodological quality was assessed using bias assessment tools.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eight\u00a0RCTs and one cohort study were included in the review with a total of 291 participants. Six studies reported a statistically significant increase in hair density in the PrP group versus the control. Five studies reported a statistically significant increase in hair count with PrP. Seven studies showed moderate risk and two showed low\u00a0risk of bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a methodologically robust review on the effectiveness of PrP on male AGA, PrP demonstrated some potential to be used therapeutically. However, the low quality of evidence, moderate risk of bias, and high heterogeneity of included studies limit inferences and call for more robust designs to investigate this further.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16185","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T04:49:13Z","timestamp":1706503753000},"page":"1551-1559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The role of platelet\u2010rich plasma in androgenetic alopecia: A systematic review"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8527-8228","authenticated-orcid":false,"given":"C.","family":"Donnelly","sequence":"first","affiliation":[{"name":"Green Templeton College University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Minty","sequence":"additional","affiliation":[{"name":"University College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dsouza","sequence":"additional","affiliation":[{"name":"Kasturba Medical College  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2393-6325","authenticated-orcid":false,"given":"Y. Y.","family":"Wong","sequence":"additional","affiliation":[{"name":"University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Conquest Hospital  Hastings UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Nagarajan","sequence":"additional","affiliation":[{"name":"University Hospital Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Rupra","sequence":"additional","affiliation":[{"name":"Norfolk &amp; Norwich University Hospital  Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. N.","family":"Charles","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Khajuria","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-014-0077-5"},{"issue":"2","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","DOI":"10.1111\/dth.14768","article-title":"Systematic review of platelet\u2010rich plasma in treating alopecia: focusing on efficacy, safety, and therapeutic durability","volume":"34","author":"Roohaninsab M","year":"2021","journal-title":"Dermatol Ther"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-019-00806-4"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2450\/2021.0216-21"},{"key":"e_1_2_11_6_1","unstructured":"NICE.Male pattern hair loss (male androgenetic alopecia).2022. Accessed November 18th 2022.https:\/\/cks.nice.org.uk\/topics\/male\u2010pattern\u2010hair\u2010loss\u2010male\u2010androgenetic\u2010alopecia\/management\/management\/"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000665"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008505-200110000-00002"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_10_1","unstructured":"AlzaidM RajV.Khajuria A. The role of platelet\u2010rich plasma in androgenetic alopecia: a systematic review.2021. 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