{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:37:52Z","timestamp":1792085872931,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To provide dermatologists with more clinical experience in treating androgenetic alopecia, we evaluated the effect and safety of combined microneedling therapy for androgenetic alopecia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      Method\n                      <jats:bold>s<\/jats:bold>\n                    <\/jats:title>\n                    <jats:p>Studies on combined microneedling for hair loss were comprehensively searched by us in PubMed, Excerpta Medica Database, and the Cochrane Library Database. The literature search spanned the period from 2012 to 2022. Inclusion and exclusion criteria were developed, and the literature was screened according to this criteria. The Cochrane Risk of Bias Tool was used to assess the quality of the studies. The researcher applied Revman 5.3 and Stata 15.1 software to analyze the data after extracting information from the data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Finally, 13 RCTs involving 696 AGA patients were included to compare the clinical effectiveness and adverse events of combined MN therapy with single MN therapy or single drug therapy for AGA. The results of meta\u2010analysis showed as follows: (1) Hair density and diameter changes: The combined MN group was significantly better than any single treatment group, and the differences were statistically significant (MD\u2009=\u200913.36, 95% CI\u2009=\u2009[8.55, 18.16],\n                      <jats:italic>Z<\/jats:italic>\n                      \u2009=\u20095.45,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001; MD\u2009=\u200918.11, 95% CI\u2009=\u2009[13.70, 22.52],\n                      <jats:italic>Z<\/jats:italic>\n                      \u2009=\u20098.04,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001; MD\u2009=\u200913.36, 95% CI\u2009=\u2009[8.55, 18.16],\n                      <jats:italic>Z<\/jats:italic>\n                      \u2009=\u20095.45,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001; MD\u2009=\u20092.50, 95% CI\u2009=\u2009[0.99, 4.02],\n                      <jats:italic>Z<\/jats:italic>\n                      \u2009=\u20093.23,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001); (2) the evaluation of satisfaction for efficacy: The doctor satisfaction rating of the combined MN group was significantly higher than that of any single treatment group, with statistical difference (RR\u2009=\u20092.03, 95% CI\u2009=\u2009[1.62, 2.53],\n                      <jats:italic>Z<\/jats:italic>\n                      \u2009=\u20096.24,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001). The difference between the two groups regarding patients satisfaction was not significant (RR\u2009=\u20093.44, 95% CI\u2009=\u2009[0.67, 17.59],\n                      <jats:italic>Z<\/jats:italic>\n                      \u2009=\u20091.49,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.14). (3) Safety: There was no statistical difference in the incidence of adverse reactions between combination therapy and monotherapy (RR\u2009=\u20090.83, 95% CI\u2009=\u2009[0.62, 1.12],\n                      <jats:italic>Z<\/jats:italic>\n                      \u2009=\u20091.22,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.22).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The combined MN group showed statistically significant improvement in hair density and diameter, and good safety compared with monotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16186","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T01:49:59Z","timestamp":1705628999000},"page":"1560-1572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Efficacy and safety of combined microneedling therapy for androgenic alopecia: A systematic review and meta\u2010analysis of\u00a0randomized clinical trials"],"prefix":"10.1111","volume":"23","author":[{"given":"Danning","family":"Pei","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Hospital of Hebei Medical University  Shijiazhuang China"},{"name":"Candidate Branch of National Clinical Research Center for Skin Diseases  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Hospital of Hebei Medical University  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