{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:31:39Z","timestamp":1788427899691,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rosacea is a prevalent chronic dermatological condition marked by facial inflammation and erythema, significantly compromising the quality of life for affected individuals. Current treatment methods for rosacea are not considered ideal because of the complex etiology of the disease. Mussel adhesive protein (MAP) is a glycoprotein derived from the foot gland of mussels. The protein exhibits anti\u2010inflammatory properties, relieves skin itching, and promotes wound healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to explore the feasibility of using MAP administered via microneedle delivery for treating rosacea and the potential molecular mechanism involved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The therapeutic effect and mechanism of MAP microneedle delivery in an LL\u201037\u2010induced rosacea\u2010like mouse model were observed using morphological and histological methods. Twenty\u2010seven patients with erythematotelangiectatic rosacea (ETR) underwent treatment once every 1\u2009month, with three treatments constituting one treatment course. The therapeutic effect was evaluated by comparing the clinical images taken at baseline, after the first treatment course, and after the second treatment course. The red value, CEA, and GFSS score were also calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In response to the microneedle delivery of MAP, innate immunity, inflammatory infiltration, and abnormal neurovascular regulation improved significantly in rosacea\u2010like mice. In the clinical experiments, the microneedle delivery of MAP significantly improved the symptoms of erythema, flushing, and telangiectasia in patients with ETR, and no obvious adverse reactions were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MAP delivered by microneedling is effective and safe for treating ETR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16190","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T04:05:20Z","timestamp":1706501120000},"page":"1654-1662","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Rosacea treatment with mussel adhesive protein delivered via microneedling: In\u00a0vivo and clinical studies"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1431-8744","authenticated-orcid":false,"given":"Yinli","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Dermatology Yanbian University Hospital  Yanji China"},{"name":"Department of Medical Cosmetology Yanbian University Hospital  Yanji China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilan","family":"Nan","sequence":"additional","affiliation":[{"name":"Department of Medical Cosmetology Yanbian University Hospital  Yanji China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3753-1297","authenticated-orcid":false,"given":"Richeng","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Dermatology Suzhou Mylike Cosmetic Hospital  Suzhou 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